Registration Dossier
Registration Dossier
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EC number: 246-278-9 | CAS number: 24468-13-1
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Hydrolysis product 2-ethylhexanol: acutely harmful to aquatic invertebrates.
Hydrolysis product HCl: acutely very toxic for aquatic invertebrates (pH dependent).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Remarks:
- Hydrolysis product 2-ethylhexanol (CAS 104-76-7)
- Effect concentration:
- 35.2 mg/L
Fresh water invertebrates
- Dose descriptor:
- EC50
- Remarks:
- Hydrolysis product HCl (CAS 7647-01-0)
- Effect concentration:
- 0.492 mg/L
Additional information
2-ethylhexyl chloroformate is expected to hydrolyse rapidly in contact with water (DT50 at 25 °C and pH 7 = 30.2 min, Safepharm, 2003) to form 2-ethylhexanol (CAS 104-76-7), hydrogen chloride (HCl, CAS 7647-01-0) and CO2. No data are available regarding the toxic effect of the parent compound to aquatic invertebrates. The toxicity of the hydrolysis product 2-ethylhexanol was assessed in a study with Daphnia magna. The EC50 (48 h) was 35.2 mg/L, indicating acutely harmful effects (Dow, 1980).
The hydrolysis product HCl showed acutely very toxic effects due to low pH: EC50 (48 h) = 0.492 mg/L (OECD, 2002).
Species | Results | Remarks | Reference |
Daphnia magna | EC50 (48 h) = 35.2 mg/L (nominal), static, Daphnia acute toxicity test | Hydrolysis product 2 -ethylhexanol; reliability: 2, key study | Dow, 1980 |
Daphnia magna
| EC50 (48 h) = 0.492 mg/L (acid equivalent to pH 5.3), semi-static, with analytical monitoring, OECD TG 202 | Hydrolysis product HCl; reliability: 2; key study | OECD, 2002 |
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