Registration Dossier
Registration Dossier
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EC number: 236-743-4 | CAS number: 13472-45-2
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Remarks:
- other: no data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- This is brief summary of a study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of subcutaneous injections of sodium tungstate on the rat.
- Author:
- Selle RM.
- Year:
- 1 942
- Bibliographic source:
- Federation Proceedings. Part I, Vol. 1, The American Society for Pharmacology and Experimental Therapeutics, Page 165.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The toxicity of repeat subcutanaeous dosing of sodium tungstate to rats was assessed.
- GLP compliance:
- no
Test material
- Reference substance name:
- Disodium wolframate
- EC Number:
- 236-743-4
- EC Name:
- Disodium wolframate
- Cas Number:
- 13472-45-2
- Molecular formula:
- Na2WO4
- IUPAC Name:
- disodium dioxotungstenbis(olate)
- Details on test material:
- - Name of test material (as cited in study report): sodium tungstate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- not specified
- Details on exposure:
- - Male and female rats received daily doses of a 0.1 M aqueous solution of sodium tungstate at the rate of 0.05 cc per 10 grams of body weight.
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- no data
- Frequency of treatment:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.1 M aqueous solution of sodium tungstate
- No. of animals per sex per dose:
- no data
- Control animals:
- yes
Examinations
- Statistics:
- no data
Results and discussion
Results of examinations
- Details on results:
- - Treated male rats weighed 26% less than the controls.
- In males, the kidneys were 45% heavier than the controls.
- In females, the kidney weights were 42% heavier than the controls although the body weight was 11% less than the controls.
- A severe drop in rectal temperature was observed in treated animals, from 100.7 to 92.5 ºF in 2 hours.
- After two hours the temperature slowly rose so that by 8 hours after the injection it had returned to 99.1 ºF.
- There were no differences between the weights of the bodies, kidneys, and adrenal glands of treated male and female rats and the control animals.
- Most of the tungsten was eliminated in the urine within 12 hours.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
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