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EC number: 236-743-4 | CAS number: 13472-45-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Insufficient information provided on methods to accurately evaluate the study. The study does not mention OECD guidelines or GLP compliance. The details of the environmental conditions for the animals were not discussed.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 965
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The acute toxicity of sodium tungstate was evaluated following intraperitoneal injection
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Disodium wolframate
- EC Number:
- 236-743-4
- EC Name:
- Disodium wolframate
- Cas Number:
- 13472-45-2
- Molecular formula:
- Na2WO4
- IUPAC Name:
- disodium dioxotungstenbis(olate)
- Details on test material:
- - Name of test material (as cited in study report): Sodium tungstate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Mus musculus, albinos variety
- Weight at study initiation: 20+/- 2 g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- physiological saline
- Details on exposure:
- The oxygenated salt had been placed in solution in physiological saline in a concentration such that the volume of liquid injected was not too high, so as to avoid shock. The animals were administered intraperitoneally in a "single dose".
- Doses:
- No data
- No. of animals per sex per dose:
- No data
- Control animals:
- yes
- Details on study design:
- The test substance was placed in solution in physiological saline and administered to the animals intraperitoneally in a single dose. The maximum-dose-never-fatal (MDNF) in 24 hours was determined, that is, the largest dose not causing any mortality. The minimum-dose-always-fatal (mDAF) in 24 hours was determined, that is, the smallest dose provoking 100% mortality in 24 hours. The mortality percentage using 10 intermediary doses between the maximum-dose-never fatal and the minimum- doses- always- fatal was then evaluated. The LD50's were calculated using the method of Kaerber and Behrens and Litchfield and Wilcoxon.
The animals were then isolated and placed under observation in strictly identical conditions (food, temperature, etc.) for 90 days. The mortality percentage was recorded each day, the behavior and state of health of the animals were observed and the LD50's were calculated. Simultaneously with the actual toxicity studies, blanks were performed in which animals of the same age and of the same weight as those dosed with the test substance received the same volume of physiological serum as that administered to the test animals by the intraperitoneal route. - Statistics:
- The LD50's were calculated using the method of Kaerber and Behrens and Litchfield and Wilcoxon.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 0.47 other: mM/kg
- Remarks on result:
- other: calculated using the method of Kaerber and Behrens
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 0.44 other: mM/kg
- Remarks on result:
- other: calculated using the method of Litchfield and Wilcoxon
- Mortality:
- See below for mortality and dismal mortality results.
- Clinical signs:
- Mice showed symptomatology during sodium tungstate intoxication. Sodium tungstate provoked prostration and a state of lethargy.
- Body weight:
- no data
- Gross pathology:
- no data
- Other findings:
- Sodium tungstate did not seem to show delayed toxicity. Nevertheless, Sodium tungstate's lethal action is fairly slow and 48 hours are necessary for it to manifest lethal action. After 48 hours, the animals recover completely and their growth is normal. They do not show any apparent traces of the poisoning to which they have been exposed.
Any other information on results incl. tables
- The LD50 for mice is 135.27 mg/kg for Sodium tungstate dihydrate.
Mortality after 24 hours
MDNF: 0.30 mM/kg
LD50 (K&B): 0.47 mM/kg
LD50 (L&W): 0.44 mM/kg
mDAF: 0.60 mM/kg
Dismal Mortality
Infralethal dose: 0.30 mM/kg
Limit LD50 (K&B): 0.44 mM/kg
Limit LD50 (L&W): 0.41 mM/kg
Per. of crisis in days: 2
Applicant's summary and conclusion
- Conclusions:
- Sodium tungstate provoked a very prompt response in mice. The period of crisis was 2 days. The i.p. LD50 for male mice was determined to be 0.44- 0.47 mM/kg-bw (dependent on method of calculation).
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