Registration Dossier
Registration Dossier
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EC number: 206-768-5 | CAS number: 373-61-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable non-guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
Test material
- Reference substance name:
- Dihydrogen bis(acetato-O)difluoroborate(1-)
- EC Number:
- 206-768-5
- EC Name:
- Dihydrogen bis(acetato-O)difluoroborate(1-)
- Cas Number:
- 373-61-5
- Molecular formula:
- BF3 x (CH3COOH)2
- IUPAC Name:
- bis(acetic acid); trifluoroborane
- Details on test material:
- Name of the test substance used in the study report: Borfluorid-Essigsaeure
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye of the same animal
- Amount / concentration applied:
- 0.05 ml of undiluted test substance
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 8 d
- Number of animals or in vitro replicates:
- 2
Results and discussion
In vivo
- Irritant / corrosive response data:
- After 8 days, dark reddening, deep necrosis and a very intense corneal opacity were observed.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information
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