Fatty acids, C16-18 and C18-unsatd., reaction products with diethylenetriamine, di-Me sulfate-quaternized

Hydrolysis

Description of key information

The half-lives of the closely related oleic-acid based IQAC, DMS quaternised were at pH 4: > 1 year at 25 °C, at pH7 2.9 days at 20°C, 2.5 days a t 25°C, 27 hours at 50 °C and 16 hours at 60 °C, respectively. At pH 9 the half life was 1.2 days at 20 °C.

Key value for chemical safety assessment

Half-life for hydrolysis:

2.9 d

at the temperature of:

20 °C

Additional information

Experimental data on hydrolysis of Partially unsaturated IQAC, DMS quaternised are not available. The substance is easily forming emulsions with water. It was not possible to remove the suspension of excess undissolved test substance by either centrifugation or filtration techniques to isolate a suitable aqueous solution for a hydrolysis study. In the guidelines (EC Guideline C.7 and OECD Guideline 111) it is outlined, that the hydrolysis test is only applicable to water soluble substances. In the frame of determing physico-chemical properties, among others the water solubility of the test substance was determined to be 2.6 mg/l using a slow stirring method (see Chapter 4.8). Based on these findings and the requirements of the guidelines, the test on hydrolysis is technically not feasible and was therefore not performed. Instead, a read across test from the closely related Oleic-acid based IQAC, DMS quaternised is available. Hydrolysis of the IQAC based on oleic acid was studied in the dark at 20ºC, 50 ºC and 60 ºC in sterile aqueous buffered solutions at pH 4 (acetate buffer), pH 7 (phosphate buffer) and pH 9 (borate buffer) for 5 days according to EC C.7 (OECD 111). The half-lives of the test item were at pH 4: > 1 year at 25 °C, at pH 7 2.9 days at 20°C, 2.5 days at 25°C, 27 hours at 50 °C and 16 hours at 60 °C, respectively. At pH 9 the half life was 1.2 days at 20 °C.