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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

- Skin irritation: not irritating
- Eye irritation: slightly irritating but not classify.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2020
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Version / remarks:
2015
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 870.2500 (Acute Dermal Irritation)
Version / remarks:
August 1998
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: EC No 440/2008 Part B. Acute Toxicity, Dermal Irritation/Corrosion
Version / remarks:
May 2008
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: Appendix to Director General Notification, No. 12-Nousan-8147. Agricultural Production Bureau, Ministry of Agriculture, Forestry and Fisheries of Japan (JMAFF)
Version / remarks:
November 2000, including revisions up to 2019
Deviations:
no
GLP compliance:
yes
Species:
rabbit
Strain:
New Zealand White
Type of coverage:
semiocclusive
Preparation of test site:
clipped
Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
0.5 mL pure substance
Duration of treatment / exposure:
4 h
Observation period:
21 d
Number of animals:
3
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Score:
>= 0 - <= 0.3
Max. score:
0.3
Reversibility:
fully reversible within: 21 d
Irritation parameter:
erythema score
Basis:
mean
Time point:
24/48/72 h
Score:
>= 1 - <= 1.3
Max. score:
1.3
Reversibility:
fully reversible within: 21 d
Conclusions:
Based on these results 3-PENTENENITRILE does not have to be classified and has no
obligatory labelling requirement for skin irritation according to the Globally Harmonized
System of Classification and Labelling of Chemicals (GHS) of the United Nations (2017)
(including all amendments up to 2019) and Regulation (EC) No 1272/2008 on classification, labelling and packaging of items and mixtures (including all amendments up to 2019)
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2019-2020
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
This in-vivo test was performed, because earlier in-vivo tests had experimental deficiencies and an in-vitro bovine cornea opacity test was inconclusive for classification.
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Version / remarks:
2017
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: EC No 440/2008 Part B. Acute Toxicity, Eye Irritation/Corrosion
Version / remarks:
May 2008
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 870.2400 (Acute Eye Irritation)
Version / remarks:
August 1998
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: Appendix to Director General Notification, No. 12-Nousan-8147. Agricultural Production Bureau, Ministry of Agriculture, Forestry and Fisheries of Japan (JMAFF)
Version / remarks:
November 2000, including recent versions up to 2019
Deviations:
no
GLP compliance:
yes
Species:
rabbit
Strain:
New Zealand White
Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
0.1 mL
Duration of treatment / exposure:
72 h
Observation period (in vivo):
1, 24, 48, 72 h
Number of animals or in vitro replicates:
3
Irritation parameter:
chemosis score
Basis:
mean
Time point:
24/48/72 h
Score:
>= 0 - <= 0.3
Max. score:
0.3
Reversibility:
fully reversible within: 72 h
Remarks on result:
other: very weak irritation, but fully reversible after 72 h
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
24/48/72 h
Score:
>= 0.3 - 1
Max. score:
1
Reversibility:
fully reversible within: 72 h
Remarks on result:
other: weak, but fully reversible irritation
Irritation parameter:
iris score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
0
Reversibility:
fully reversible
Remarks on result:
no indication of irritation
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
0
Reversibility:
fully reversible
Remarks on result:
no indication of irritation
Conclusions:
Based on these results, 3-PENTENENITRILE does not have to be classified and has no
obligatory labelling requirement for eye irritation according to the Globally Harmonized
System of Classification and Labelling of Chemicals (GHS) of the United Nations (2017)
(including all amendments) and Regulation (EC) No 1272/2008 on classification, labelling
and packaging of items and mixtures (including all amendments)
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Justification for classification or non-classification

The substance does not need to be classified according to GLP as irritating for skin and eyes.