N-sodiohexamethyldisilazane

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Information from published industry source (USEPA), minor limitations in design and/or reporting but otherwise adequate for assessment

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1992

Report date:

1992

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The acute oral toxicity was determined in rats employing a modified procedure in "Appraisel of the Safety of Chemicals in Foods, Drugs and Costmetics, Published by the Association of Food and Drug Officials of the U.S. (1959)".

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

1,1,1,3,3,3-hexamethyldisilazane

EC Number:

213-668-5

EC Name:

1,1,1,3,3,3-hexamethyldisilazane

Cas Number:

999-97-3

Molecular formula:

C6H19NSi2

IUPAC Name:

1,1,1-trimethyl-N-(trimethylsilyl)silanamine

Details on test material:

- Name of test material (as cited in study report): Hexamethyldisilazane
- Physical state: Clear colorless liquid

Test animals

Species:

rat

Strain:

Long-Evans

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age at study initiation: adult
- Fasting period before study: 18 hours
- Diet: ad libitum
- Water: ad libitum

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Remarks:

1% (v/v)

Doses:

0.05, 0.1, 0.25, 0.5, 0.9, 0.95, 1, 2.5 mL/kg

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Other examinations performed: clinical signs

Statistics:

The acute oral toxicity LD50 for rats was calculated accoring to the method of Miller and Tainter (Proc. Soc. Med. 57, 261 (1944).

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

1 mL/kg bw

Based on:

test mat.

Mortality:

- No mortality observed in animals exposed to 0.05, 0.1, 0.25, 0.5 or 0.9 mL/kg.
- 7 out of 10 animals exposed to 0.95 mL/kg died, within 2 days after exposure.
- 6 out of 10 animals exposed to 1 mL/kg died, within 2 days after exposure.
- All animals exposed to 2.5 mL/kg died, within 2 days after exposure.

Clinical signs:

other: - Decreased activity and ataxia observed in animals exposed to 0.05, 0.1 or 0.25 mL/kg. - Decreased activity or sedation, ataxia or incoordination, urinary incontinence, decreased respiration observed in animals exposed to 0.5 mL/kg. - Sedation, incoordin

Gross pathology:

- Lungs pinkish grey colour, liver mottled and spleen granular in animals exposed to 0.05 mL/kg.
- Lungs and liver mottled and spleen granular in animals exposed to 0.1 mL/kg.
- Liver and kidneys mottled, and granular spleen in animals exposed to 0.25 mL/kg.
- Lungs puffy and mottled, and spleen granular in animals exposed to 0.5 mL/kg.
- Lung mottled, liver dark in colour, spleen pale and granular, kidneys pale and mottled in animals exposed to 0.9 mL/kg.
- Lungs mottled, spleen granular, kidneys pale and mottled, and skin vascularized in animals exposed to 0.95 mL/kg.
- Lungs, liver and kidneys mottled, spleen granular, and skin vascularized in animals exposed to 1 mL/kg.
- Lungs mottled, liver dark, spleen granular, and kidneys pale and mottled in animals exposed to 2.5 mL/kg.

Applicant's summary and conclusion

Interpretation of results:

harmful

Remarks:

Migrated information