3,5-dimethylhex-1-yn-3-ol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1972

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Test done before GLP and Guidelines were established.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1972

Report date:

1972

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Single Exposure

A group of ten , male, albino rats weighing between 200 and 500 grams each was used in this study, The rats were placed i n a 70 liter all glass exposure chamber and exposed to a saturated atmosphere of the test material in air for one hour, The material was administered
as an aerosol with particles 3 - 5 microns in diameter. The rate of flow was 23,9 liters per minute at a temperature of 76 °F. The air was passed through a dessicant prior to being passed through the test material.
By differential weighing it was calculated that the rats were subjected to a concentration of 19,700 ppm. This is an average value over the one hour exposure period.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3,5-dimethylhex-1-yn-3-ol

EC Number:

203-500-9

EC Name:

3,5-dimethylhex-1-yn-3-ol

Cas Number:

107-54-0

Molecular formula:

C8H14O

IUPAC Name:

3,5-dimethylhex-1-yn-3-ol

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

whole body

Vehicle:

air

Duration of exposure:

1 h

Concentrations:

19,700 ppm

No. of animals per sex per dose:

10 male

Control animals:

no

Results and discussion

Any other information on results incl. tables

All of the rats survived the one hour exposure period. During the exposure period the rats at first huddled together and their breathing increased in depth. After exposure the rats exhibited complete muscular rigidity with shallow respiration. They remained like this for from one to eight hours and then recovered and were normal throughout the remainder of the observation period. In all rats their eyes appeared normal immediately after removal from the exposure chamber and remained normal throughout the entire observation period. At the end of the 14 day observation period all rats were subjected to gross autopsy examination.

All rats appeared normal on gross examination.

Applicant's summary and conclusion

Interpretation of results:

other: non toxic

Remarks:

Criteria used for interpretation of results: OECD GHS

Conclusions:

From the results obtained in this study it appears that Surfynol 61 would be considered non toxic.
The one hour LC50 is greater than 19.7 mg/l. This converts to a four hour LC50 greater than 4.9 mg/l

Executive summary:

From the results obtained in this study it appears that Surfynol 61 would be considered non toxic.

The one hour LC50 is greater than 19.7 mg/l. This converts to a four hour LC50 greater than 4.9 mg/l