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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The substance was not irritating to rabbit skin, but irritating to the eyes of rabbits.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin irritation:

In a GLP-compliant OECD guideline 404 study, rabbits were exposed to Nocolok Zn Flux to determine skin irritating properties. 0.5 g of the test substance moistened with 0.2 mL Milli-U water were applied under semi-occlusive conditions to the skin of 3 rabbits for 4 hours. After the removal of the patches animals were observed for 72 hours. No evidence of skin irritation was noted (erythema and edema scores were 0 at all time points (24, 48 and 72 hours) in all animals). Based on the results of the study, Nocolok Zn Flux is considered to be not irritating to skin.

Eye irritation:

In a GLP-compliant OECD guideline 405 study, rabbits were exposed to Nocolok Zn Flux to determine eye irritating properties. 97 mg of Nocolok Zn Flux were instilled into the eye of each of three rabbits. Observations were made 1, 24, 48 and 72 hours and 7, 14 and 21 days after instillation. No staining and no systemic toxicity was observed. Opacity was seen in all animals and also as slight dulling of the normal lustrein in one animal. As a result of the corneal injury, pannus (neovascularisation of the cornea) was apperent in two animals 7 days after instillation. The corneal injury and/or pannus had resolved in one animal within 72 hours and in two animals within 14 days. Irridial irritation (grade 1) was observed in two animals and had resolved within 72 hours and 7 days respectively. Redness, chemosis, and discharge was completely resolved in one animal within 14 days and in the other two within 21 days. Reduced elasticity of the eyelids was seen in one animal 72 hours after instillation and resolved within 14 days. Based on the results the test substance was considered to be irritating to the eyes.


Justification for selection of skin irritation / corrosion endpoint:
GLP-compliant guideline study.

Justification for selection of eye irritation endpoint:
GLP-compliant guideline study.

Effects on eye irritation: irritating

Justification for classification or non-classification

Based on the findings in the skin irritation study the test substance does not need to be classified according to the Directive 67/548/EEC and according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008. Based on the results of the eye irritation study the test substance needs to be classified as Xi: R36 according to the Directive 67/548/EEC and Cat 2: H319 according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.