Registration Dossier
Registration Dossier
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EC number: 700-183-3 | CAS number: 52299-25-9
Endpoint summary
Administrative data
Description of key information
With the test item one oral toxicity study was conducted. No mortality, no body weight change and no signs of toxicity were observed at a dose of 50 mg/kg bw. A single dose of 300 mg/kg bw caused mortality with clinical signs of intoxication. The LD50 is considered to be in the range of 50 to 300 mg/kg bw. No acute toxicity studies for dermal or inhalative administration are available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- discriminating dose
Additional information
Oral route of administration
The test item was tested for acute toxicity in rats after oral administration of 50 and 300 mg/kg body weight. This study was performed according to the ,,Acute toxic class method" (ATC).
No signs of toxicity were detected in the 3 male and 3 female rats after treatment with 50 mg/kg and no rat died. The gross pathological examination revealed no organ alterations. Treatment with 300 mg/kg bw resulted in mortality and severe clinical effects in 3 female rats.
Summary
Based on the result of this study, the test item can be considered to have an acutely toxic potential and to have a LD50 between 50 and 300 mg/kg after oral application to rats.
Justification for classification or non-classification
Based on the results for acute oral and dermal toxicity in rats, the test item is considered to have an acutely toxic potential. The LD50 value is in the range of 50 to 300 mg/kg bw after oral administration to rats.
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