Registration Dossier
Registration Dossier
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EC number: 611-210-2 | CAS number: 54914-95-3
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline used
Data source
Reference
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 4-aminotoluene-3-sulphonic acid
- EC Number:
- 201-831-3
- EC Name:
- 4-aminotoluene-3-sulphonic acid
- Cas Number:
- 88-44-8
- IUPAC Name:
- 2-amino-5-methylbenzenesulfonic acid
- Details on test material:
- Wako Pure Chemical Industries, Ltd.: purity >95%
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test organisms
- Test organisms (species):
- Oryzias latipes
Study design
- Test type:
- semi-static
- Limit test:
- no
- Total exposure duration:
- 96 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- > 10 mg/L
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 10 mg/L
Any other information on results incl. tables
- Sublethal observations / clinical signs:
CONCENTRATION
nominal concentration measured concentration (mg/l)
0 hr fresh 48 hr expired
------------------------------------------------------------
-control <0.1 <0.1
solvent control <0.1 <0.1
10 10 10
As the results, measured concentration was equal to nominal
one.
EFFECTS
no abnormal behaviour, no abnormal respiration nor dead one
were observed in any those dose levels
MONITORING DATA
water temperature 23.7-23.8 °C
dissolved oxygen 6.2-8.3 mg/l (saturated concentration at
24 °C is 8.25 mg/l)
pH: 7.5-7.8
REMARK
This study was limit test at 10 mg/l only, due to author's
misunderstanding to the solubility in water (ref section
2.6.1)
Therefore it was no real limit test
Applicant's summary and conclusion
- Conclusions:
- 96hr LC50 (and LC0) for Oryzias latipes is > 10mg/L.
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