Registration Dossier
Registration Dossier
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EC number: 920-427-4 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The sensitising potential of Zorgol 48 (1-Hexanol, 2-ethyl-, manuf. of, by-products from, distn. Residues) can be assessed based on the results of a local lymph node test (OECD 429, EU B.42).
In a local lymph node assay, adult female CBA/CaOlaHsd mice (4 animals per group) were tested with Zorgol 48 using concentrations of 25, 50, and 100% (vehicle acetone/olive oil 4:1).
No effects were noticed on body weight development and no signs of systemic toxicity were seen. No skin irritation was observed at the application sites for any test concentration.
Incorporation of radioactivity in lymph nodes was increased for all test concentrations over controls (SI 2.02, 4.83, and 5.75 respectively).EC3was determined to be33.7%. In this study,Zorgol 48is aweak dermal sensitizer(Vogel/Laus, 2010).
Migrated from Short description of key information:
In a local lymph node assay, Zorgla 48 was shown to be a weak dermal sensitizer
Justification for classification or non-classification
Based on the results of a local lymph node test, Zorgol 48 (1-Hexanol, 2-ethyl-, manuf. of, by-products from, distn. Residues) is classified as sensitising according to Directive 67/548/EEC and as skin sensitizer (Category 1) according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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