N-[3-(dimethylamino)propyl]dodecanamide N-oxide

Water solubility

Administrative data

Endpoint:

water solubility

Remarks:

by critical micelle concentration (CMC)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

05 Feb - 20 Feb 2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2020

Report date:

2020

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

other: EC A.5

Deviations:

not specified

Test guideline 2

Qualifier:

according to guideline

Guideline:

other: OECD 115

Deviations:

not specified

Test guideline 3

Qualifier:

according to guideline

Guideline:

other: ISO 4311

Deviations:

not specified

GLP compliance:

yes

Type of method:

other: OECD harmonised ring method for CMC determination

Test material

Test material information

Constituent 1

Reference substance name:

N-[3-(dimethylamino)propyl]dodecanamide N-oxide

EC Number:

263-218-7

EC Name:

N-[3-(dimethylamino)propyl]dodecanamide N-oxide

Cas Number:

61792-31-2

Molecular formula:

C17H36N2O2

IUPAC Name:

N-[3-(dimethylamino)propyl]dodecanamide N-oxide

Results and discussion

Water solubility

Water solubility:

68 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

Remarks on result:

other: CMC measurement

Any other information on results incl. tables

Results:

Preliminary test--

The results of the test solutions prepared on the first day to estimate the CMC, are summarized below. The individual measurements were obtained with a coefficient of variation of < 0.2 mN/m. The estimated critical micelle concentration was 69 mg/L.

 

Surface tension was measured at 1.002 mg/L, 10.018 mg/L, 100.86 mg/L, 1005.9 mg/L, and 10016 mg/L. Measured average values, respectively, were: 71.34 mN/m, 54.39 mN/m, 22.35 mN/m, 27.95 mN/m, and 29.67 mN/m.

 

Main study--

The results of the main study on the determination of the CMC on the second day, are summarized below. The individual measurements were obtained with a coefficient of variation of < 0.2 mN/m.

 

Surface tension was measured at 5.0017 mg/L, 25.029 mg/L, 50.273 mg/L, 201.94 mg/L, and 500.88 mg/L. Measured average values, respectively, were: 64.97 mN/m, 39.35 mN/m, 31.13 mN/m, 22.86 mN/m, and 25.43 mN/m.

 

Summary of the Determination of the Surface Tension of the Test Item Solutions:

Sample	Concentration C[mg/L]	Log C	Surface tension [mN/m]
1	5.0017	0.7	64.97
2	25.029	1.4	39.35
3	50.273	1.7	31.13
4	201.94	2.3	22.86
5	500.88	2.7	25.43
6	2031.7	3.3	28.97

The results above were used for calculation of the log C value. The plot of the surface tension of the test solutions as function of log C is summarized by 2 trendlines. The CMC was determined from the intersection of the two trendlines y1 and y2. Trendline y1 was obtained using the data of the test solutions with test item concentrations of 5.0017, 25.029 and 50.273 mg/L. Trendline y2 was obtained from the mean surface tension of the test solutions with test item concentrations of 201.94, 500.88 and 2031.7 mg/L. The intersection was calculated to be at a log C value of 1.83. It corresponded with a CMC of 68 mg/L.

 

Plot of Surface tension versus log C (concentration)-- 

Trendline y1 has equation: y1 = -34.267x + 88.542

Trendline y2 has equation: y2 = 25.753

 

Conclusion--

The CMC of the test item was determined by measuring the surface tension of test item solutions at different test item concentrations. The Critical Micelle Concentration (CMC) of the test item is 68 mg/L.

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