Registration Dossier
Registration Dossier
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EC number: 403-470-9 | CAS number: - CYANEX (R) EXTRACTANT; CYANEX 923 EXTRACTANT
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- A mixture of: hexyldioctylphosphineoxide; dihexyloctylphosphineoxide; trioctylphosphineoxide
- IUPAC Name:
- A mixture of: hexyldioctylphosphineoxide; dihexyloctylphosphineoxide; trioctylphosphineoxide
- Test material form:
- liquid: viscous
Constituent 1
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
Study design
- Test type:
- static
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.21 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.17 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.16 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.14 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 0.32 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.056 mg/L
- Nominal / measured:
- nominal
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The results of the 96-hour stat~c toxicity test with rainbow trout (Salmo gairdneri) exposed to the test substance showed that 24-, 48-, 72- and 96-hour LC 50 values for the test subtance are 0,21, 0.17, 0.15 and 0,14 mg/L, respectively. All results were based on the nominal concentrations of 0.018, 0.032, 0.056, 0.10, 0.18 and 0.32 mg/L. The 96-hour no-observed effect concentration was estimated to be 0.056 mg/L, based on the lack of mortality or observed abnormal (sub-lethal) effects.
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