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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
not applicable
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: data from peer-reviewed database

Data source

Referenceopen allclose all

Reference Type:
other: secondary source
Title:
High Production Volume (HPV) Challenge Program's Robust Summaries and Test Plans for Acetylene
Author:
EPA, Office of Pollution Prevention and Toxics
Year:
2006
Bibliographic source:
EPA/Office of Pollution Prevention and Toxics; HPV Challenge Program's Robust Summaries and Test Plans for Acetylene (December 2003). Available from, as of September 10, 2006: http://www.epa.gov/chemrtk/pubs/summaries/acetylen/c15005.pdf
Reference Type:
secondary source
Title:
TOXNET
Author:
HSDB database
Year:
2004
Bibliographic source:
https://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
not specified in database
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Propyne
EC Number:
200-828-4
EC Name:
Propyne
Cas Number:
74-99-7
Molecular formula:
C3H4
IUPAC Name:
prop-1-yne
Test material form:
gas
Specific details on test material used for the study:
no details given

Test animals

Species:
rat
Details on test animals or test system and environmental conditions:
no details given

Administration / exposure

Route of administration:
inhalation
Details on inhalation exposure:
the animals were exposed to 28,700 ppm methylacetylene 6 hr/day, 5 days/week for 6 months
Doses / concentrations
Dose / conc.:
28 700 ppm
No. of animals per sex per dose:
no details given
Details on study design:
no details given

Results and discussion

Results of examinations

Clinical signs:
effects observed, treatment-related
Description (incidence and severity):
Rats reached an early plane of anesthesia (within 30 minutes) and generally recovered rapidly after each exposure.
Mortality:
mortality observed, treatment-related
Description (incidence):
Forty percent of the rats died over the course of the study.
Body weight and weight changes:
not specified
Food consumption and compound intake (if feeding study):
not specified
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
not specified
Clinical biochemistry findings:
not specified
Urinalysis findings:
not specified
Behaviour (functional findings):
effects observed, treatment-related
Description (incidence and severity):
Rats reached an early plane of anesthesia (within 30 minutes) and generally recovered rapidly after each exposure.
Immunological findings:
not specified
Organ weight findings including organ / body weight ratios:
not specified
Gross pathological findings:
effects observed, treatment-related
Description (incidence and severity):
Gross pathology of the rats that died was limited to the lungs, which appeared dark red and remained distended when the thorax was opened.
In exposed rats that survived to termination, the lungs also were discolored and remained distended.
Neuropathological findings:
not specified
Histopathological findings: non-neoplastic:
effects observed, treatment-related
Description (incidence and severity):
Microscopic pathology of the lungs showed definite pulmonary irritation.
Histopathological findings: neoplastic:
not specified
Other effects:
not specified

Effect levels

Remarks on result:
other: see "Any other information on results"

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Rats reached an early plane of anesthesia (within 30 minutes) and generally recovered rapidly after each exposure. Forty percent of the rats died over the course of the study. Gross pathology of the rats that died was limited to the lungs, which appeared dark red and remained distended when the thorax was opened. In exposed rats that survived to termination, the lungs also were discolored and remained distended. Microscopic pathology of the lungs showed definite pulmonary irritation. The remaining organs appeared to be within normal limits.

Applicant's summary and conclusion

Executive summary:

There is no available information on the methods used to determine the value for this endpoint. However, this information is taken from the TOXNET website which is considered to be a reliable peer reviewed data source.

In this study, the rats were exposed to 28,700 ppm methylacetylene 6 hr/day, 5 days/week for 6 months.

Rats reached an early plane of anesthesia (within 30 minutes) and generally recovered rapidly after each exposure. Forty percent of the rats died over the course of the study. Gross pathology of the rats that died was limited to the lungs, which appeared dark red and remained distended when the thorax was opened. In exposed rats that survived to termination, the lungs also were discolored and remained distended. Microscopic pathology of the lungs showed definite pulmonary irritation. The remaining organs appeared to be within normal limits.