Registration Dossier
Registration Dossier
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EC number: 256-783-6 | CAS number: 50814-31-8 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 40215.
Endpoint summary
Administrative data
Description of key information
Aquatic invertebrates:
OECD 202, 1991, EC50 (48h) > 1000 mg/l.
OECD 202, 2003, EC50 (48h) > 100 mg/l.
Aquatic algae:
OECD 201, 1991,EC50(96h) > 1000 mg/l.
OECD 201, 2003, EC50 (72 -96h) > 100 mg/l
Additional information
No data on target substance was available, thus the assessment relied on a read across approach using available data on Similar Substance 01 and 02. Details on the read across procedure are attached in section 13.
Both target substance and read across substance are not ready biodegradable and are soluble in water at 20 °C. In particular, water solubility of target substance is ca. 39 g/l and of Similar Substance 01 is 142 g/l. Due to the structural similarity, solubility of Similar Substance 02 is expected to be comparable.
Short-term toxicity to aquatic invertebrates
Similar Substance 01 and 02 were tested for acute toxicity to daphnia magna in 48 -hour static tests according to OECD guideline 202. Effects on mobility were recorded.
Similar Substance 01 was tested at concentrations up to 1000 mg/l. Measured concentrations in test medium were between 29.2 and 41.7 % of nominal values, likely due to precipitation, which was seen in test solutions as well as in samples for analytical measurements. However, measured concentration of stock solution was 102.4 % of nominal value.
Similar Substance 02 was tested at concentrations up to 100 mg/l.
In both cases, test substance had no effect of mobility of daphnids, thus EC50 (48h) > 100 mg/l.
Toxicity to aquatic algae and cyanobacteria
Green algae were exposed to Similar Substance 01 and 02 under static exposure conditions for 96 h and 72 h, respectively, according to OECD guideline 201.
Concentrations up to 1000 mg/l of Similar Substance 01 and 100 mg/l of Similar Substance 02 were tested. Toxic effects were recorded in terms of inhibition of growth rate. At the end of exposure period, growth rate inhibition at the highest tested concentration was ca. 19 % with Similar Substance 01 and ca. 29 % with Similar Substance 02. Therefore, ErC50 (72 - 96h) > 100 mg/l.
Justification for classification or non-classification
According to the CLP Regulation (EC 1272/2008), the threshold of classification of a substance for acute aquatic toxicity is 1 mg/l. This limit is compared with EC50 (48h) for daphnia and EC50 (72 - 96h) for algae or aquatic plants.
As for chronic toxicity, in case of lack of chronic data, the toxic potential is identified by appropriate combinations of acute toxicity data and lack of biodegradability. The threshold of classification is 100 mg/l.
In case of poorly soluble substances, the threshold for classification is identified as the solubility limit of the substance.
Based on EC50 values obtained, no classification for both acute and chronic toxicity was applied according to the CLP Regulation (EC 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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