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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
The study did not meet current guideline requirements for repeated dose toxicity.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1968

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Trimethoxysilane
EC Number:
219-637-2
EC Name:
Trimethoxysilane
Cas Number:
2487-90-3
Molecular formula:
C3H10O3Si
IUPAC Name:
Trimethoxysilane

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
two weeks
Frequency of treatment:
5 days/weeek
Doses / concentrations
Remarks:
Doses / Concentrations:
0.2 ml/kg bw
Basis:
actual ingested
No. of animals per sex per dose:
5/sex/group
Control animals:
no
Details on study design:
Test material was administered as a single dose intubation using calibrated syringe and a suitable catheter. Material was administered in the undiluted form (0.2 ml/kg) to 5 male and 5 female rats. 

Examinations

Sacrifice and pathology:
Pathological observation was made on representative animals.

Results and discussion

Results of examinations

Clinical signs:
effects observed, treatment-related
Mortality:
mortality observed, treatment-related
Histopathological findings: non-neoplastic:
effects observed, treatment-related
Details on results:
Oral administration of 0.2 ml/kg trimethoxysilane caused 5 deaths and abnormal kidney pathology.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
In a pre-GLP, non-guideline repeated dose toxicity study (reliability score 4) 0.2 ml/kg bw undiluted trimethoxysilane was administered by oral gavage five days/week for two weeks, to five male and five female rats. Pathological examinations were conducted on representative animals. There were five deaths and abnormal kidney pathology.