Registration Dossier
Registration Dossier
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EC number: 219-637-2 | CAS number: 2487-90-3
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: human accidental exposure information
- Adequacy of study:
- weight of evidence
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Clinical and Experimental Investigation of Ocular Damage Caused by Trimethoxysilane
- Author:
- Tamura, A., Yuri, H., Maruyama, H. and K. Maruyama
- Year:
- 1 968
- Bibliographic source:
- Jap Opthalmol So 72(1):|40-47. Cited in AIHAJ Workplace Environmental Exposure Level Guides: Trimethoxysilane (1997).
- Reference Type:
- publication
- Title:
- Rationale Document for Trimethoxysilane. Union Carbide.
- Author:
- Plevan RE
- Year:
- 1 991
- Bibliographic source:
- Cited in AIHAJ (1997) Workplace Environmental Exposure Level Guides: Trimethoxysilane (1997)
Materials and methods
- Study type:
- poisoning incident
Test guideline
- Qualifier:
- no guideline required
- GLP compliance:
- no
Test material
- Reference substance name:
- Trimethoxysilane
- EC Number:
- 219-637-2
- EC Name:
- Trimethoxysilane
- Cas Number:
- 2487-90-3
- Molecular formula:
- C3H10O3Si
- IUPAC Name:
- Trimethoxysilane
Constituent 1
Method
- Subjects:
- Six workers exposed.
No other data - Route of exposure:
- inhalation
- Reason of exposure:
- accidental
- Exposure assessment:
- not specified
Results and discussion
- Clinical signs:
- Six workers engaged in purification of the test substance experienced irritation, pain, lacrimation and disturbance of vision 8-12 hours after work. Eye examinations revealed conjunctival hyperemia, chemosis and desquamation of the corneal epithelium. Healing took 20-90 days. Two of the six workers developed a sore throat and four suffered bronchitis or bronchopneumonia.
Applicant's summary and conclusion
- Conclusions:
- In a short summary (reliability score 4) of a human accidental incident six workers engaged in purification of the test substance experienced irritation, pain, lacrimation and disturbance of vision 8-12 hours after work. Eye examinations revealed conjunctival hyperemia, chemosis and desquamation of the corneal epithelium. Healing took 20-90 days. Two of the six workers developed a sore throat and four suffered bronchitis or bronchopneumonia.
- Executive summary:
In a short summary (reliability score 4) of a human accidental incident six workers engaged in purification of the test substance experienced irritation, pain, lacrimation and disturbance of vision 8-12 hours after work. Eye examinations revealed conjunctival hyperemia, chemosis and desquamation of the corneal epithelium. Healing took 20-90 days. Two of the six workers developed a sore throat and four suffered bronchitis or bronchopneumonia.
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