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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
not applicable
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well documented and scientifically good . Not according to GLP nor to specific test guidelines.
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study
Principles of method if other than guideline:
A study was conducted to evaluate the acute oral toxicity of the test material in rats. The rats were exposed to a dose of 2.000mg/kg bw and observed during a period of 14 days

GLP compliance:
not specified
Test type:
acute toxic class method
Limit test:
yes
Species:
rat
Strain:
Wistar
Sex:
female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: firma Harlan
- Weight at study initiation: ± 190g
- Housing: individual cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12

Route of administration:
oral: unspecified
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
none
Doses:
2000mg/kg bw
No. of animals per sex per dose:
4
Control animals:
yes
Details on study design:
- Duration of observation period following administration: 14 days
Statistics:
no statistics reported
Sex:
female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
no deaths observed
Clinical signs:
no data
Body weight:
slight increases
Gross pathology:
no data
Other findings:
none

none       

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The sample Cenizas de cinc de segunda fusion is not harmful neither toxic via the oral route
Executive summary:

This study report demonstrated no acute oral toxicity for the sample 'Cenizas de cinc de segunda fusion'

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
not applicable
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well documented and scientifically good . Not according to GLP nor to specific test guidelines.
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to other study
Principles of method if other than guideline:
A study was conducted to evaluate the acute dermal toxicity of the test material in rats. The rats were exposed to a dose of 2.000mg/kg bw of the test material and observed during a period of 14 days
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no
Species:
rat
Strain:
Wistar
Sex:
female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: firma Harlan
- Weight at study initiation: ± 190g
- Housing: individual cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Duration of exposure:
14 days observation period
Doses:
2000mg/kg bw
No. of animals per sex per dose:
4
Control animals:
yes
Details on study design:
- Duration of observation period following administration: 14 days
Statistics:
no statistics reported
Sex:
female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
no deaths
Clinical signs:
no data
Body weight:
slight increases
Gross pathology:
no data
Other findings:
none

none              

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The sample 'Cenizas de cinc de segunda fusion' is not harmful neither toxic via the dermal route
Executive summary:

This study report demonstrated no acute dermal toxicity for the sample 'Cenizas de cinc de segunda fusion'

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Additional information

Justification for classification or non-classification

A study was conducted to evaluate the acute oral toxicity of the test material in rats. The rats were exposed to a dose of 2.000mg/kg bw and observed during a period of 14 days and an LD50>2000 mg/kg bw was observed, which is justifying no classfication for acute oral toxicity.

A study was conducted to evaluate the acute dermal toxicity of the test material in rats. The rats were exposed to a dose of 2.000mg/kg bw and observed during a period of 14 days and an LD50>2000 mg/kg bw was observed, which is justifying no classfication for acute dermal toxicity.