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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

All three in vitro tests in genetic toxicity showed negative results. Therefore, there is no need to carry out in vivo studies in genetic toxicity. There is no reason to believe that the negative results would not be relevant to humans.


Justification for selection of genetic toxicity endpoint
Conclusion based on the following assays: Bacterial reverse mutation assay (Ames test); Mammalian cell gene mutation assay; In vitro mammalian chromosome aberration test.
Read across from ammonium dihydrogenorthophosphate and diammonium phosphate to magnesium ammonium phosphate is considered justified based on following background:
Since magnesium ammonium phosphate, ammonium dihydrogenorthophosphate and diammonium phosphate dissociate to their respective ammonium, (magnesium) and phosphate ions, it is considered acceptable to approach the assessment of magnesium ammonium phosphate based on the individual components.
Phosphate, ammonium and magnesium, as essential nutrients for life are not known as mutagenic.
Given the previous evaluations of magnesium, ammonium and phosphate salts as food additives and as nutrient sources by the EFSA (European Food Safety Authority), SCF (Scientific Committee on Food ) BfR (Federal Institute for Risk Assessment) and JECFA (Joint FAO/WHO Expert Committee on Food Additives) and taking into account that available information on their toxicity did not identify toxicogical effects, any additional testing would be unjustified.

Short description of key information:
Negative in all tests conducted:
Bacterial reverse mutation assay with diammonium phosphate:
The results of the Bacterial Reverse Mutation Assay according to OECD guideline 471 indicate that, under the conditions of the study, Diammonium Phosphate (DAP) did not cause a positive response in the presence and absence of Aroclor-induced rat liver S9.

In vitro mamalian chromosome aberration assay with diammonium phosphate:
Under the conditions of the assay according to OECD guideline 473, Diammoniumn Phosphate (DAP) was concluded to be negative for the induction of
structural and numerical chromosome aberrations in CHO cells.

Mammalian cell gene mutation assay with ammonium dihydrogenorthophosphate:
Ammonium dihydrogenorthophosphate was not mutagenic in the mouse lymphoma L5178Y test system under the experimental conditions according to OECD guideline 476.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

According to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations (2007) and Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures the substance is not classified.