Ammonium magnesium orthophosphate

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Study period:

1980

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study is well documented and performed similar to OECD 404 guideline.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Deviations:

yes

Remarks:

24 h exposure under occlusive conditions

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Monoammonium phosphate

IUPAC Name:

Monoammonium phosphate

Constituent 2

Reference substance name:

Härter 26 Pulver

IUPAC Name:

Härter 26 Pulver

Constituent 3

Reference substance name:

Ammonium dihydrogenorthophosphate

EC Number:

231-764-5

EC Name:

Ammonium dihydrogenorthophosphate

Cas Number:

7722-76-1

IUPAC Name:

ammonium dihydrogen phosphate

Test material form:

solid: crystalline

Test animals

Species:

rabbit

Strain:

Vienna White

Details on test animals or test system and environmental conditions:

TEST ANIMALS

- Weight at study initiation: females: 3.54 kg, males: 2.95

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

water

Controls:

no

Amount / concentration applied:

0.5 g of 80 % aqueous solution

Duration of treatment / exposure:

24 hours

Observation period:

9 days

Number of animals:

3 male and 3 female

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

mean

Time point:

other: 24, 72 hours

Score:

0.25

Max. score:

1

Reversibility:

fully reversible within: 72 hours

Results 2

Irritation parameter:

edema score

Basis:

mean

Time point:

other: 24, 72 hours

Score:

0

Max. score:

0

Any other information on results incl. tables

	time	animal 1	animal 2	animal 3	animal 4	animal 5	animal 6
erythema	24 h	1	1	0	0	0	1
	72 h	0	0	0	0	0	0
	9 d	0	0	0	0	0	0
edema	24 h	0	0	0	0	0	0
	72 h	0	0	0	0	0	0
	9 d	0	0	0	0	0	0

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated information Criteria used for interpretation of results: OECD GHS

Conclusions:

Monoammonium phosphate was slightly irritant to the rabbits skin in an in vivo study according to the methods of Draize.
According to the CLP-criteria no classification is justified.