Thieno[3,4-b]-1,4-dioxin-5,7-dicarboxylic acid, 2,3-dihydro-

Guidance on Safe Use

First-aid measures

Inhalation: Move exposed person to fresh air. Keep prosn warm and at rest. If

not breathing, if breathing is irregular or if respiratory arrest occurs,

provide artificial respiration or oxygen by trained personnel. It may

be dangerous to the person providing aid to give mouth-to-mouth

resuscitation. Get medical attention if adverse health effects persist

or are severe. If unconscious, place in recovery position and get

medical attention immediately. Maintain an open airway. Loosen tight clothing such as collar, tie, belt or waistband.

Ingestion: Wash out mouth with water. Move exposed person to fresh air.

Keep person warm and at rest. If material has been swallowed and

the exposed person is conscious, give small quantities of water to

drink. Stop if the exposed person feels sick as vomiting may be

dangerous. Do not induce vomiting unless directed to do so by

medical personnel. If vomiting occurs, the head should be kept low

so that vomit does not enter the lungs. Get medical attention if

adverse health effects persist or are severe. Never give anything by

mouth to an unconscious person. If unconscious, place in recovery

position and get medical attention immediately. Maintain an open

airway. Loosen tight clothing such as a collar, tie, belt or waistband.

Skin contact: Flush contaminated skin with plenty of water. Remove contaminated

clothing and shoes. Get medical attention if symptoms occur. Wash

clothing before reuse. Clean shoes thoroughly before reuse.

Eye contact: Immediately flush eyes with plenty of water, occasionally lifting the

upper and lower eyelids. Check for and remove any contact lenses.

Continue to rinse for at least 10 minutes. Get medical attention if irritation occurs.

Fire-fighting measures

Suitable extinguishing media:

In case of fire, use water spray (fog), foam, dry chemical or CO2.

Unsuitable extinguishing media: None known

Hazards from the substance or mixture: No specific fire or explosion hazard.

Hazardous combustion products: No specific data.

Special precautions for fire-fighters: Promptly isolate the scene by removing all persons from the vicinity

of the incident if there is a fire. No action shall be taken involving any

personal risk or without suitable training. This material is harmful to

aquatic organisms. Fire water contaminated with this material must

be contained and prevented from being discharged to any waterway, sewer or drain.

Special protective equipment for fire-fighters: Fire-fighters should wear appropriate protective equipment and selfcontained

breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode.

Accidental release measures

Personal precautions, protective equipment and emergency procedures:

No action shall be taken involving any personal risk or without

suitable training. Keep unnecessary and unprotected personnel from

entering. Do not touch or walk through spilt material. Provide

adequate ventilation. Put on appropriate personal protective equipment.

Environmental precautions: Avoid dispersal of spilt material and runoff and contact with soil,

waterways, drains and sewers. Inform the relevant authorities if the

product has caused environmental pollution (sewers, waterways, soil

or air). Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.

Large spill: Move containers from spill area. Prevent entry into sewers, water

courses, basements or confined areas. Vacuum or sweep up

material and place in a designated, labelled waste container.

Dispose of via a licensed waste disposal contractor.

Small spill: Move containers from spill area. Vacuum or sweep up material and

place in a designated, labelled waste container. Dispose of via a licensed waste disposal contractor.

Handling and storage

Manufacture and use of this chemical intermediate takes place under strictly controlled conditions, as described in Art. 17/18 REACH. The substance is rigorously contained during manufacturing and use and appropriate risk management measures including PPE (i.g. during charging or sampling) are applied. Occupational exposure is reduced to a minimum and well controlled by measurements. A management system covering all general aspectsof a chemical production is in place, especially cleaning and maintenance of plants and equipment. An authorisation scheme based on instructions covering the whole process ensures that only trained and authorised staff handles the substance.

Precautions for safe handling: Put on appropriate personal protective equipment.

Eating, drinking and smoking should be prohibited in areas where this

material is handled, stored and processed. Workers should wash

hands and face before eating, drinking and smoking. Do not ingest.

Avoid contact with eyes, skin and clothing. Keep in the original

container or an approved alternative made from a compatible

material, kept tightly closed when not in use. Empty containers retain product residue and can be hazardous.

Conditions for safe storage, including any incompatibilities: Store in accordance with local regulations. Store in original container

protected from direct sunlight in a dry, cool and well-ventilated area,

away from incompatible materials and food and drink. Keep container tightly closed and sealed until ready for use.

Containers that have been opened must be carefully resealed and

kept upright to prevent leakage. Do not store in unlabelled

containers. Use appropriate containment to avoid environmental contamination.

The product is registered with strictly controlled conditions as defined in Article 17(3) or 18(4) of the regulation (EC) no. 1907/2006 (REACH regulation) and must therefore be handled as such. Refer to industry guidance prepared by Concawe/Cefic/EFCG for advice on the confirmation of strictly controlled conditions.

Transport information

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Shipping

Remarks

SpecialProvisions

Exposure controls / personal protection

Recommended monitoring procedures : If this product contains ingredients with exposure limits, personal,

workplace atmosphere or biological monitoring may be required to

determine the effectiveness of the ventilation or other control

measures and/or the necessity to use respiratory protective

equipment. Reference should be made to European Standard EN

689 for methods for the assessment of exposure by inhalation to

chemical agents and national guidance documents for methods for the determination of hazardous substances.

Risk management measures

Technical measures : If this product contains ingredients with exposure limits, use process

enclosures, local exhaust ventilation or other engineering controls to

keep worker exposure below any recommended or statutory limits.

Personal protection measures

Respiratory protection: Use a properly fitted, air-purifying or air-fed respirator complying with

an approved standard if a risk assessment indicates this is

necessary. Respirator selection must be based on known or

anticipated exposure levels, the hazards of the product and the safe

working limits of the selected respirator.

Recommended: In case of dust formation particle filter.

Hand protection: Chemical-resistant, impervious gloves complying with an approved

standard should be worn at all times when handling chemical

products if a risk assessment indicates this is necessary. After

contamination with product change the gloves immediately and

dispose of them according to relevant national and local regulations

Recommended: (< 1 hour) polyvinyl chloride (PVC) or Rubber

gloves.

Eye protection: Safety eyewear complying with an approved standard should be

used when a risk assessment indicates this is necessary to avoid

exposure to liquid splashes, mists, gases or dusts.

Recommended: safety glasses with side-shields

Skin protection: Personal protective equipment for the body should be selected

based on the task being performed and the risks involved and should

be approved by a specialist before handling this product.

Recommended: Wear protective clothing.

Hygiene measures:  Wash hands, forearms and face thoroughly after handling chemical

products, before eating, smoking and using the lavatory and at the

end of the working period. Appropriate techniques should be used to

remove potentially contaminated clothing. Wash contaminated

clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation location.

Environmental expsosure controls:

Technical measures: Emissions from ventilation or work process equipment should be

checked to ensure they comply with the requirements of

environmental protection legislation. In some cases, fume

scrubbers, filters or engineering modifications to the process

equipment will be necessary to reduce emissions to acceptable

levels.

Stability and reactivity

Reactivity: No specific test data related to reactivity available for this product or its ingredients.

Chemical stability: The product is stable.

Possibility of hazardous reactions: Under normal conditions of storage and use, hazardous reactions will not occur.

Conditions to avoid: In the case of dusty organic products the possibility of a dust explosion should always be considered. No hazardous reactions when used as directed.

Incompatible materials: No specific data.

Hazardous decomposition products: Under normal conditions of storage and use, hazardous decomposition products should not be produced.

Disposal considerations

Methods of disposal : Examine possibilities for re-utilisation. Product residues and

uncleaned empty containers should be packaged, sealed, labelled,

and disposed of or recycled according to relevant national and local

regulations. Where large quantities are concerned, consult the

supplier. When uncleaned empty containers are passed on, the

recipient must be warned of any possible hazard that may be caused

by residues. For disposal within the EC, the appropriate code

according to the European Waste List (EWL) should be used. It is

among the tasks of the polluter to assign the waste to waste codes

specific to industrial sectors and processes according to the

European Waste List (EWL).

Hazardous waste: The classification of the product may meet the criteria for a hazardous waste.

Methods of disposal : The generation of waste should be avoided or minimised wherever

possible. Waste packaging should be recycled. Incineration or

landfill should only be considered when recycling is not feasible.

Special precautions : This material and its container must be disposed of in a safe way.

Care should be taken when handling emptied containers that have

not been cleaned or rinsed out. Empty containers or liners may

retain some product residues. Avoid dispersal of spilt material and

runoff and contact with soil, waterways, drains and sewers.