Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: GLP study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1995

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method B.1 (Acute Toxicity (Oral))
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2H,3H-thieno[3,4-b][1,4]dioxine-5,7-dicarboxylic acid
EC Number:
605-999-2
Cas Number:
18361-03-0
Molecular formula:
C8H6O6S
IUPAC Name:
2H,3H-thieno[3,4-b][1,4]dioxine-5,7-dicarboxylic acid

Test animals

Species:
rat
Strain:
other: SPF-bred, strain: Hsd Spb:WU
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: 0.9 % NaCl solution
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
5 male
5 female

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU