Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 228-391-5 | CAS number: 6258-06-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Manufacturer / producer data without proof.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
- Reference Type:
- publication
- Title:
- Toxicity and ecotoxicity of sulfonic acids: structure-activity relationship
- Author:
- Greim H et al.
- Year:
- 1 994
- Bibliographic source:
- Chemosphere Vol. 28, No. 12, pp. 2203-2236
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Sodium 1-amino-4-bromo-9,10-dioxoanthracene-2-sulphonate
- EC Number:
- 228-391-5
- EC Name:
- Sodium 1-amino-4-bromo-9,10-dioxoanthracene-2-sulphonate
- Cas Number:
- 6258-06-6
- Molecular formula:
- C14H8BrNO5S.Na
- IUPAC Name:
- sodium 1-amino-4-bromo-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate
- Details on test material:
- no data
Constituent 1
Method
- Target gene:
- his-operon
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Details on mammalian cell type (if applicable):
- No data.
- Metabolic activation:
- with and without
- Metabolic activation system:
- No data.
- Test concentrations with justification for top dose:
- no data
Controls
- Untreated negative controls:
- not specified
- Positive controls:
- not specified
- Details on test system and experimental conditions:
- no data
- Evaluation criteria:
- no data
- Statistics:
- no data
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- positive
- Remarks:
- on S. typhimurium TA 100 and TA 98 a biologically relevant increase in the mutant count compared to the corresponding negative control was found; positive response was found only with S9 mix
- Cytotoxicity / choice of top concentrations:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
positive with metabolic activation in TA100, TA98
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
