Registration Dossier
Registration Dossier
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EC number: 201-152-2 | CAS number: 78-87-5
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
A toxicity test was conducted with the marine diatom (Skeletonema costatum) exposed to 1,2-dichloropropane under sealed-vessel conditions, under GLP, in general accordance to standard methods, and resulted in a 72-hour ErC50 value 15.4 mg/L and NOEC of 8.50 mg/L.
Key value for chemical safety assessment
- EC50 for marine water algae:
- 15.4 mg/L
- EC10 or NOEC for marine water algae:
- 8.5 mg/L
Additional information
The 1,2 -dichloropropane study by Dow (1988) with the marine diatom (Skeletonema costatum) was selected as the key study because it was conducted under sealed-vessel conditions with measured confirmation of doses and in general accordance with standard methods. The 72 -hour ErC50 value was 15.4 mg/L and the 72 -hour growth rate NOEC was 8.50 mg/L.
The remaining 5 supporting studies were not considered key studies due to unsuitable test design or insufficient data available for reliable assessment (e.g. 48 -hour test, no cell count data available for calculation of 72 -hour endpoint values, poor biological response). None of the supporting studies provided the required 72 -hour EC50 and NOEC for growth rate.
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