Registration Dossier
Registration Dossier
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EC number: 939-154-7 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline study under GLP condition
Data source
Reference
- Reference Type:
- publication
- Title:
- Single dose oral toxicity test of sodium p-toluenesulfonate in rats.
- Author:
- MHLW, Japan (Ministry of Health, Labour and Welfare)
- Year:
- 2 001
- Bibliographic source:
- Japan Toxicity Testing Reports of Environmental Chemicals, 8, 773-774. (2001a)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Sodium p-toluenesulphonate
- IUPAC Name:
- Sodium p-toluenesulphonate
- Details on test material:
- IUCLID4 Test substance: other TS: Sodium p-toluenesulfonate (Lot No. 980900), Purity: 92.7 wt%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
Administration / exposure
- Vehicle:
- other: distilled water
- Doses:
- 0, 2000 mg/kg bw
- No. of animals per sex per dose:
- 5/sex/dose
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
Any other information on results incl. tables
[Mortality / Clinical signs]
No deaths occurred during the study.Diarrhea was observed for both sexes in the 2000 mg/kg bw groups.
[Body weight]
There were no treatment-related changes in body weight in either sex.
[Necropsy]
No macroscopic abnormalities were observed at autopsy in either sex.
LD50 in male and female rats were greater than 2000 mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Criteria used for interpretation of results: EU
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