Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 232-075-2 | CAS number: 7785-21-9
Toxicological information
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 24.4 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: ECETOC
- Overall assessment factor (AF):
- 18
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 440 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- comparable systemic effects after exposure by inhaltion and by oral uptake expected
- AF for dose response relationship:
- 1
- Justification:
- NOAEL available
- AF for differences in duration of exposure:
- 6
- Justification:
- default value for extrapolation subacute -> chronic
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- not required due to allometric scaling
- AF for other interspecies differences:
- 1
- Justification:
- default value
- AF for intraspecies differences:
- 3
- Justification:
- default value
- AF for the quality of the whole database:
- 1
- Justification:
- high quality of database
- AF for remaining uncertainties:
- 1
- Justification:
- not required
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.47 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: ECETOC
- Overall assessment factor (AF):
- 72
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 250 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- The bioavailability after oral exposure is higher than after dermal expsoure, hence the data from oral studies are considered to be worst case figures.
- AF for dose response relationship:
- 1
- AF for differences in duration of exposure:
- 6
- Justification:
- default value for extrapolation subacute -> chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- default value for extrapolation rat -> man
- AF for other interspecies differences:
- 1
- Justification:
- default value
- AF for intraspecies differences:
- 3
- Justification:
- default value for workers
- AF for the quality of the whole database:
- 1
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 7.2 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: ECETOC
- Overall assessment factor (AF):
- 30
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 217 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- comparable systemic effects after exposure by inhaltion and by oral uptake expected
- AF for dose response relationship:
- 1
- Justification:
- NOAEL available
- AF for differences in duration of exposure:
- 6
- Justification:
- default value for extrapolation subacute -> chronic
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- not required due to allometric scaling
- AF for other interspecies differences:
- 1
- Justification:
- default value
- AF for intraspecies differences:
- 5
- Justification:
- default value for general population
- AF for the quality of the whole database:
- 1
- Justification:
- high quality of database
- AF for remaining uncertainties:
- 1
- Justification:
- not required
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.1 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: ECETOC
- Overall assessment factor (AF):
- 120
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 250 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- The bioavailability after oral exposure is higher than after dermal expsoure, hence the data from oral studies are considered to be worst case figures.
- AF for dose response relationship:
- 1
- Justification:
- NOAEL available
- AF for differences in duration of exposure:
- 6
- Justification:
- default value for extrapolation subacute -> chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- default value for extrapolation rat -> man
- AF for other interspecies differences:
- 1
- Justification:
- default value
- AF for intraspecies differences:
- 5
- Justification:
- default value for general population
- AF for the quality of the whole database:
- 1
- Justification:
- high quality of database
- AF for remaining uncertainties:
- 1
- Justification:
- not required
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.1 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other: ECETOC
- Overall assessment factor (AF):
- 120
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 250 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- NOAEL available
- AF for differences in duration of exposure:
- 6
- Justification:
- default value for extrapolation subacute -> chronic
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- default value for extrapolation rat -> man
- AF for other interspecies differences:
- 1
- Justification:
- default value
- AF for intraspecies differences:
- 5
- Justification:
- default value for general population
- AF for the quality of the whole database:
- 1
- Justification:
- high quality of database
- AF for remaining uncertainties:
- 1
- Justification:
- not required
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
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