Reaction mass of m-cresol and 2-chloro-m-cresol and 6-chloro-m-cresol

Endpoint summary

Additional information

The relevant data on toxicity on terrestrial organisms for Preventol KMX and the read across substance 4-chloro-3-methylphenol are summarized in the table below. The read across justification and additional data for m-cresol are attached to the Chemical Safety Report in Annex I. In comparison to the chlorocresols, m-cresol is only a minor component of Preventol KMX. Therefore these data are not considered for the assessment of the toxicity on terrestrial organisms of Preventol KMX.

Table 1: Comparison of relevant data on toxicity on terrestrial organisms of Preventol KMX and 4-chloro-3-methylphenol

Endpoint	Preventol KMX	4-chloro-3-methylphenol
Toxicity to soil macroorganisms except arthropods	Read across 4-chloro-3-methylphenol	OECD 207 Eisenia fetida LC50 (14d): 139.4 mg/kg soil dw
Toxicity to terrestrial plants	Read across 4-chloro-3-methylphenol	OECD 208 Avena sativa NOEC (14d) = 14.6 mg/kg soil dw
Toxicity to soil microorganisms	Read across 4-chloro-3-methylphenol	OECD216 N-transformation EC50 (28d): 555.1 mg/kg soil dw NOEC (28d): 300 mg/kg soil dw

No toxicity studies on terrestrial organisms for the reaction mass are available. The substance is a mixture of four different m-cresols which are similar in physico-chemical properties, environmental fate and metabolism.

For one of the components of the reaction mass (4-chloro-m-cresol, CAS No. 59-50-7) terrestrial toxicity was investigated for plants, soil macroorganisms and soil microorganisms. These studies are used as read across for the reaction mass. The 14-day study with plants revealed an EC50 of 27.7 mg/kg soil dw and a LOEC of 15 mg/kg dw. For earthworms an EC50 (14d) of 139.4 mg/kg soil dw was determined. For the nitrogen transformation of soil microorganisms an NOEC (28d) of 300 mg/kg soil dw was determined.