Registration Dossier
Registration Dossier
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EC number: 410-210-8 | CAS number: -
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005-07-15 to 2005-08-31
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD study, GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil
Test material
Constituent 1
Study design
HPLC method
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Varian autosampler ProStar 410, Varian pump ProStar 230, Varian DAD detector ProStar 330, Jones column oven 7990
- Type: high performance liquid chromatograph with UV/VIS detector
- Type, material and dimension of analytical (guard) column:
- Detection: Test item: 508 nm, Reference item: 210 nm, Sodium nitrate: 210 nm
MOBILE PHASES
- Type: Water / acetonitrile (45:55; v/v)
- Experiments with additives carried out on separate columns: no
- pH: 6.7
-- Solutes for dissolving test and reference substances: The test item was dissolved in dimethylformamide
DETERMINATION OF DEAD TIME
- Method: by inert substances which are not retained by the column
REFERENCE SUBSTANCES
- Identity: Sodium nitrate; Acetanilide
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 20 µl
REPETITIONS
- Number of determinations: three times
EVALUATION
- Calculation of capacity factors k': The capacity factor (k') is calculated from the retention time of the reference items, the test item (tr) and an unretarded item (to):
k' = (tr-to)/to
- Determination of the log Koc value: The log k' value of the test item was used to calculate its log Koc value.
Y= a+b*X
X= (Y-a)/b
where
Y = log k' values
X = log Koc values
a = Y-axis intercept of the regression curve
b = Slope
Results and discussion
Adsorption coefficient
- Type:
- log Koc
- Value:
- < 1.25
- Temp.:
- 25 °C
Results: HPLC method
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: Reference Item Acetanilide = 2.956; Sodium nitrate (= dead time) ca. 1.211
- Average retention data for test substance: ca. 1.176
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
