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Diss Factsheets
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EC number: 219-606-3 | CAS number: 2478-10-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- occlusive conditions; readings after 72 hrs missing, only two animals tested
- Principles of method if other than guideline:
- Occlusive conditions were used during exposure. Reading after 72 h is missing and only two animals were tested.
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-hydroxybutyl acrylate
- EC Number:
- 219-606-3
- EC Name:
- 4-hydroxybutyl acrylate
- Cas Number:
- 2478-10-6
- Molecular formula:
- C7H12O3
- IUPAC Name:
- 4-hydroxybutyl acrylate
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Butanediolmonoacrylate
- Chemical name: 2-Propenoic acid, 4-hydroxy ester
- Analytical purity: >= 94 %
- Substance No.: 77/759
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gaukler, 6050 Offenbach / Main, Germany
- Sex: male
- Age at study initiation: no data
- Mean body weight at study initiation: males 3.0 kg
- Diet (ad libitum): Ssniff K, standard diet for rabbits, INTERMAST GmbH, Soest, Germany
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
no details given
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Remarks:
- 15 - 24 hrs before test start
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin areas of the same animals
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 4 hours or 5 min
- Observation period:
- 8 days
- Number of animals:
- 2 per timepoint
- Details on study design:
- 4 h exposure:
TEST SITE
- Area of exposure: flank and back, 2 x 2 cm
- Type of wrap if used: the test patch which was wetted with the test substance was applied to the dorsal skin of the rabbits by means of a gummed linen patch that was fastened by an adhesive dressing.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, with lutrol or lutrol:water (1:1)
- Time after start of exposure: 4 hrs
SCORING SYSTEM: Draize Scoring System (1959)
5 min exposure:
TEST SITE
- Area of exposure: flank and back, 2.5 x 2.5 cm
- Type of wrap if used: the test patch which was wetted with the test substance was applied to the dorsal skin of the rabbits by means of a gummed linen patch that was fastened by an adhesive dressing.
REMOVAL OF TEST SUBSTANCE
- Washing: yes, with lutrol or lutrol:water (1:1)
- Time after start of exposure: 5 min
SCORING SYSTEM: Draize Scoring System (1959)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- (4h exposure)
- Time point:
- 24/48 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: findings extending far beyond the area of application
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- (4h exposure)
- Time point:
- 24/48 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: findings (ery., ed.) extending beyond the area of application
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- (4h exposure)
- Time point:
- 24/48 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: findings (ery., ed.) extending beyond the area of application
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- (4h exposure)
- Time point:
- 24/48 h
- Score:
- 2.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: findings (ery., ed.) extending beyond the area of application
- Irritation parameter:
- erythema score
- Basis:
- animal: #1, #2
- Remarks:
- (5 min exposure)
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal: #1, #2
- Remarks:
- (5 min exposure)
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- Application for 4 hours produced marked erythema (grade 3) and slight to very strong edema (grades 2-4) in 2/2 rabbits (observed at 4, 24 and 48 hours). After 8 days, slight erythema (grade 2) and slight edema (grade 2) still persisted in 2/2 and 1/2 rabbits, respectively. Scaling respectively severe scaling was observed in both animals. Corrosive effects in form of necrosis were not observed in any animal.
Both animals did not show a local irritation reaction upon 5 min exposure to the test substance.
Any other information on results incl. tables
Raw data for 4 h exposure:
Readings |
Animal No. |
Erythema |
Edema |
Additional findings |
4 h |
1 |
3 |
4 |
findings (ery., ed.) extending far beyond the area of application |
|
2 |
3 |
3 |
findings (ery., ed.) extending beyond the area of application |
24 h |
1 |
3 |
4 |
findings (ery., ed.) extending far beyond the area of application |
|
2 |
3 |
3 |
findings (ery., ed.) extending beyond the area of application |
48 h |
1 |
3 |
2 |
findings (ery., ed.) extending far beyond the area of application, severe desquamation |
|
2 |
3 |
2 |
findings (ery., ed.) extending beyond the area of application |
8 d |
1 |
2 |
0 |
scaling |
|
2 |
2 |
2 |
findings (ery., ed.) extending beyond the area of application, severe scaling |
No effects were visible following a 5 min application.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
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