Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-606-3 | CAS number: 2478-10-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
- Principles of method if other than guideline:
- BASF Test: Several groups of 5 NMRI (Ivanova) mice per sex and dose were treated simultaneously i.p. with aqueous solutions of the test substance. Group-wise documentation of clinical signs was performed over the 14-day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose. The clinical signs and findings were reported in summary form.
On the basis of the observed lethality, the LD50 value was estimated or determined using a graphical evaluation of the dose response curve on probability paper. - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 4-hydroxybutyl acrylate
- EC Number:
- 219-606-3
- EC Name:
- 4-hydroxybutyl acrylate
- Cas Number:
- 2478-10-6
- Molecular formula:
- C7H12O3
- IUPAC Name:
- 4-hydroxybutyl acrylate
Constituent 1
- Specific details on test material used for the study:
- Test substance: Butanediolmonoacrylate
Chemical name: 2-Propenoic acid, 4-hydroxy ester
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ivanova
- Mean body weights at study initiation: males 26.7 g, females 24.0 g
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw
- Doses:
- 1470, 1000, 681, 464, 316, and 215 µL/kg bw (corresponding to approx. 1529, 1040, 708, 483, 329, and 224 mg/kg bw)
Recalculation based on density = 1.04 g/cm3 at 25 °C (BASF AG, MSDS, 2007) - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Cageside observations were performed several times on the day of administration and daily on workdays during the observation period. Body weights were determined at test start only.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 483 - 708 mg/kg bw
- Based on:
- test mat.
- Mortality:
- At the two highest doses all treated animals died within the first hour after substance administration. At 708 mg/kg bw 7/10 animals died within 24 hrs, after 48 hrs 10/10 animals had expired. At the three lower doses, no mortality occurred.
- Clinical signs:
- Signs of toxicity comprised dyspnoea, apathy, lateral-abdominal position, staggering, twitching, saltatory convulsions, tremor, fibrillary convulsions, clonic convulsions, and poor general state.
- Body weight:
- Body weight gain during the course of the study was reported to be normal.
- Gross pathology:
- Deceased animals: liver degeneration.
Sacrificed animals: no adverse abnormalities observed at gross-pathological examination.
Any other information on results incl. tables
Original value: LD50 > 460 < 680 µL/kg bw; therefore LD50 > approx. 478 < approx. 707 mg/kg bw (density = 1.04 g/mL).
Mortality:
Dose [mg/kg bw] |
Conc. [%] |
No. of animals/sex |
Dead animals / treated animals after |
||||
|
|
|
1 h |
24 h |
48 h |
7 d |
14 d |
1529 |
14.7 |
5 m |
5/5 |
5/5 |
5/5 |
5/5 |
5/5 |
5 f |
5/5 |
5/5 |
5/5 |
5/5 |
5/5 |
||
1040 |
10 |
5 m |
5/5 |
5/5 |
5/5 |
5/5 |
5/5 |
5 f |
5/5 |
5/5 |
5/5 |
5/5 |
5/5 |
||
708 |
6.81 |
5 m |
0/5 |
4/5 |
5/5 |
5/5 |
5/5 |
5 f |
0/5 |
3/5 |
5/5 |
5/5 |
5/5 |
||
483 |
4.64 |
5 m |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
5 f |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
||
329 |
3.16 |
5 m |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
5 f |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
||
224 |
2.15 |
5 m |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
5 f |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
f: female
m: male
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.