Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 907-873-5 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Ames test: Negative (OECD TG 471, GLP)
Additional information
Ames test
The substance is tested in the Ames test (OECD TG 471) following GLP. The test was performed in two independent experiments, at first a direct plate assay was performed and secondly a pre-incubation assay. In the first mutation experiment, the test item was tested up to concentrations of 5000 μg/plate in the strains TA100, TA1535, TA1537, TA98, and WP2uvrA. The test item did not precipitate on the plates at this dose level. Cytotoxicity was observed in tester strain TA100 at a dose level of 5000 μg/plate in the presence of S9-mix, and in tester strain TA1537 at a dose level of 5000 μg/plate in the absence of S9-mix. In the second mutation experiment, the test item was tested up to concentrations of 5000 μg/plate in the tester strains TA1537, TA98, TA100 and WP2uvrA in the pre-incubation assay. Tester strain TA1535 was exposed to concentrations up to 5000 μg/plate in the absence of S9-mix and 1600 μg/plate in the presence of S9-mix. The test item did not precipitate on the plates at this dose level. Cytotoxicity was observed in all tester strains in the absence and presence of S9-mix, except in WP2uvrA. The negative and strain-specific positive control values were within the laboratory historical control data ranges indicating that the test conditions were adequate and that the metabolic activation system functioned properly. In conclusion, based on the results of this study it is concluded that Citronellyl Propionate is not mutagenic in the Salmonella typhimurium reverse mutation assay and in the Escherichia coli reverse mutation assay.
Justification for classification or non-classification
Based on the results of the Ames test, the substance does not need to be classified for genotoxicity according to EU CLP (EC 1272/2008 and its amendments).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
