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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

1
Chemical structure
Reference substance name:
Reaction mass of 3,7-dimethyloct-6-en-1-yl propanoate and 3,7-dimethyloctyl propanoate
EC Number:
907-873-5
Molecular formula:
C13H24O2 C13H26O2
IUPAC Name:
Reaction mass of 3,7-dimethyloct-6-en-1-yl propanoate and 3,7-dimethyloctyl propanoate
Test material form:
liquid

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: gavage
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
10 animals per dose
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Mortality, clinical signs

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
Three animals died during the study. Two animals died on day 1 and the third on day 6.
Clinical signs:
other: Clinical signs included slow response and lethargy.

Applicant's summary and conclusion

Interpretation of results:
other: not acute harmful according to EU CLP Regulation (EC) No. 1272/2008 and its amendments
Conclusions:
The acute oral toxicity test showed an LD50 of >5000 mg/kg bw.
Executive summary:

In an acute oral toxicity study performed similar to OECD 401 (pre-OECD and pre-GLP), 10 rats were administered the test substance orally at a dose level of 5000 mg/kg bw. The animals were observed for mortality and clinical signs for 14 days. Three animals died during the study. Two animals died on day 1 and the third on day 6. Clinical signs included slow response and lethargy. The acute oral LD50 for the test substance in rats was determined to be >5000 mg/kg bw.