Registration Dossier
Registration Dossier
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EC number: 228-207-3 | CAS number: 6168-72-5
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- see Methods: limited experiment due to full miscibility in both n-octanol and water
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- yes
- Remarks:
- see below "details on methods"
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- estimation method (solubility ratio)
- Remarks:
- see below "details on methods"
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- DL-2-aminopropan-1-ol
- EC Number:
- 228-207-3
- EC Name:
- DL-2-aminopropan-1-ol
- Cas Number:
- 6168-72-5
- Molecular formula:
- C3H9NO
- IUPAC Name:
- 2-aminopropan-1-ol
1
Study design
- Analytical method:
- gas chromatography
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- ca. -1
- Temp.:
- 20 °C
- pH:
- 10.5
- Remarks on result:
- other: pH relates to aqueous phase; log Kow in 2 assays: -1.2 and -0.8
Applicant's summary and conclusion
- Executive summary:
Due to the technical impossibility to follow HPLC screening or ratio of direct solubilities in n-octanol and water (the test item being fully miscible in both media), a specific method was followed.
The concentration of the test item was quantified in an aqueous stock solution as well as in its aqueous phase after mixing with n-octanol, centrifugation and separation. The concentration in corresponding n-octanol phase was deduced by difference from the concentration in stock solution. The ratio of concentrations in aqueous and n-octanol phases enabled to conclude that Log Kow was approximately -1.0 (mean of 2 assays) at 20°C and a pH of 10.6 (in aqueous phase).
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