Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 2020-12-08 to 2020-12-09
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 13 April 2004
- Deviations:
- no
- GLP compliance:
- no
- Other quality assurance:
- ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Batch No.: CN0191205
Purity: 98.3% - Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 2.732
- Remarks on result:
- other: Temperature and pH not specified
- Details on results:
- The retention time of test item was determined parallel twice, and the two values were 8.427 min and 8.423 min respectively. The capacity factor k of test item was calculated by retention time respectively. The lgk of test item was brought into regression equation Y=0.492X-0.618 (R=0.988, the values of lgPow of test item were 2.732 and 2.732 respectively, the absolute difference of the two lgPow values was 0 units and the average of lgPow of test item was 2.732, the Pow value was 539.51.
- Conclusions:
- The average of lgPow of test item was 2.732, the Pow value was 539.51.
- Executive summary:
The Partition Coefficient (n-octanol/water) of test item was determined with High Performance Liquid Chromatography (HPLC) method based on OECD 117. Six compounds were selected as reference substances and the linear regression graph of lgk versus lgPow of six reference substances was plotted, the regression equation was Y=0.492X-0.618 (R=0.988). Thiourea was used for determination of dead time (t0). The retention time of thiourea, test item and six compounds mixture were determined twice respectively, the average lgPow of test item was 2.732, and the Pow was 539.51.
Reference
Description of key information
The Partition Coefficient (n-octanol/water) of test item was determined with High Performance Liquid Chromatography (HPLC) method according to OECD 117. The retention time of thiourea, test item and six compounds mixture were determined twice respectively, the average lgPow of test item was 2.732, and the Pow was 539.51.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.732
Additional information
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