Monopentaerythritol tetraesters and dipentaerythritol hexaesters of 2-ethylhexanoic and n-valeric acids

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Remarks:

Summary of available data used for the endpoint assessment of the target substance

Adequacy of study:

key study

Justification for type of information:

Please refer to the Analogue Justification provided in IUCLID Section 13.

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Duration:

48 h

Dose descriptor:

EL50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Remarks:

WAF

Basis for effect:

mobility

Remarks on result:

other:

Remarks:

source, CAS 647028-25-9, Croda, 2000, D.magna, RL2

Duration:

48 h

Dose descriptor:

NOELR

Effect conc.:

>= 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Remarks:

WAF

Basis for effect:

mobility

Remarks on result:

other:

Remarks:

source, CAS 647028-25-9, Croda, 2000, D.magna, RL2

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

> 1.3 mg/L

Nominal / measured:

meas. (geom. mean)

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other:

Remarks:

source, CAS 67762-53-2, Chemtura, 2012, D.magna, RL1

Duration:

48 h

Dose descriptor:

EL50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Remarks:

WAF

Basis for effect:

mobility

Remarks on result:

other:

Remarks:

source, CAS 67762-53-2, Chemtura, 2012, D.magna, RL1

Duration:

48 h

Dose descriptor:

NOEC

Effect conc.:

0.63 mg/L

Nominal / measured:

meas. (geom. mean)

Conc. based on:

test mat.

Basis for effect:

mortality

Remarks on result:

other:

Remarks:

source, CAS 67762-53-2, Chemtura, 2012, D.magna, RL1

Duration:

48 h

Dose descriptor:

NOELR

Effect conc.:

46 other: % of a WSF prepared at a loading rate of 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Remarks:

WAF

Basis for effect:

mobility

Remarks on result:

other:

Remarks:

source, CAS 67762-53-2, Chemtura, 2012, D.magna, RL1

Duration:

48 h

Dose descriptor:

EL50

Effect conc.:

> 1 072 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Remarks on result:

other:

Remarks:

source, CAS 711010-76-9, Exxon, 2006, D.magna, RL1

Description of key information

No effects up to the highest concentration tested; read-across.

Additional information

No study investigating the short-term toxicity of Monopentaerythritol tetraesters and dipentaerythritol hexaesters of 2-ethylhexanoic and n-valeric acids to aquatic invertebrates is available. Therefore, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substances Dipentaerythritol with fatty acids, C5 and C9iso (CAS 647028-25-9), Carboxylic acids, C5-9, tetraesters with pentaerythritol (CAS 67762-53-2) and Decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9), is applied.

Based on the high degree of similarity between the structural and physico-chemical properties of the target and source substances, the source substances are considered as suitable representative for the evaluation of the short-term toxicity of the target substance to aquatic invertebrates. The read-across approach is justified in detail within the analogue justification in IUCLID section 13.

The first study investigated the acute toxicity effects of the source substance Dipentaerythritol with fatty acids, C5 and C9iso (CAS 647028-25-9) to aquatic invertebrates according to OECD guideline 202. The test was conducted with Daphnia magna.The study was set up in a static test system. Daphnids were exposed to a water accommodated fraction (WAF) with a limit loading rate of 100 mg/L. At test termination after 48 h an EL50 > 100 mg/L based on nominal loading rate was determined.
The short-term toxicity of source substance Carboxylic acids, C5-9, tetraesters with pentaerythritol (CAS 67762-53-2) to aquatic invertebrates was conducted according to OECD 202 under static conditions. A nominal loading rate of 100 mg/L (prepared as WAF), corresponding to a measured concentration of 1.3 mg/L, was tested. No immobilisation was observed in the treatment throughout the test period of 48 h. The 48 h-EL50 is determined to be > 100 mg/L based on the nominal loading rate and > 1.3 mg/L based on the measured concentration.
The last study investigated the acute toxicity effects of the source substance Decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS No. 71010-76-9) to Daphnia magna according to OECD 202 under static conditions. Loading rate WAFs of 62, 132, 251, 503 and 1072 mg/L were tested. No immobilisation was observed in any treatment and the control throughout the test period of 48 h. Hence, the 48 h-EL50 is determined to be > 1072 mg/L based on the nominal loading rate.

Based on the available results from structurally related source substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that Monopentaerythritol tetraesters and dipentaerythritol hexaesters of 2-ethylhexanoic and n-valeric acids will not exhibit short-term effects to aquatic invertebrates up to the highest concentration/loading rate tested.