Registration Dossier
Registration Dossier
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EC number: 207-365-7 | CAS number: 465-65-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Corrositex
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Naloxone
- EC Number:
- 207-365-7
- EC Name:
- Naloxone
- Cas Number:
- 465-65-6
- Molecular formula:
- C19H21NO4
- IUPAC Name:
- (1S,5R,13R,17S)-10,17-dihydroxy-4-(prop-2-en-1-yl)-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one
1
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: reaction time (h)
- Value:
- > 4
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Non corrosive for the skin
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