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EC number: 277-918-5 | CAS number: 74543-22-9
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic/sediment
From CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model (2017) in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical), the bioaccumulation i.e BCF for test substance sodium hydrogen 8-aminonaphthalene-1,6-disulfonate was estimated to be 2.46 dimensionless . The predicted BCF result based on the 5 OECD principles. Thus based on the result it is concluded that the test substance sodium hydrogen 8 -aminonaphthalene-1,6 -disulfonate is non-bioaccumulative in nature.
Additional information
Bioaccumulation: aquatic/sediment
Predicted data for the target compound sodium hydrogen 8-aminonaphthalene-1,6-disulfonate (CAS No. 74543-22-9) and supporting weight of evidence study for its read across substance were reviewed for the bioaccumulation end point which are summarized as below:
In aprediction done using the OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model of CompTox Chemistry Dashboard (2017) where calculation was based on the PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical), the bioaccumulation i.e BCF for test substance sodium hydrogen 8-aminonaphthalene-1,6-disulfonate was estimated to be 2.46 dimensionless . The predicted BCF result based on the 5 OECD principles. Thus based on the result it is concluded that the test substance sodium hydrogen 8 -aminonaphthalene-1,6 -disulfonate is non-bioaccumulative in nature.
In a supporting weight of evidence study from authoritative database (J-CHECK, 2017 and EnviChem, 2014) for read across substance2-amino-5-methylbenzene sulfonic acid (CAS no. 88-44-8), bioaccumulation experiment was conducted on test organism Cyprinus carpio for 6 weeks for evaluating the bioconcentration factor (BCF value) of read across substance 2-amino-5-methylbenzene sulfonic acid. The study was performed according to other guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances". Cyprinus carpio was used as a test organism for the study. Test chemical nominal conc. used for the study were 2 mg/l and 0.2 mg/l, respectively. Range finding study involve the TLm (48hr) 480 mg/l (w/v) on Rice fish (Oryzias latipes).The bioconcentration factor (BCF value) of substance 2-amino-5-methylbenzene sulfonic acid on Cyprinus carpio was determined to be ≤ 0.4 L/Kg at a conc. of 2 mg/l and ≤ 4 L/Kg at a conc. of 0.2 mg/l, respectively.
For the read across chemical sodium 4-aminonaphthalene-1-sulfonate (CAS no. 130-13-2), bioaccumulation experiment was conducted on test organism Cyprinus carpio for 6 weeks for evaluating the bioconcentration factor (BCF value) of substance sodium 4-aminonaphthalene-1-sulfonate (CAS no. 130 -13 -2) under static conditions (J-CHECK, 2017). The study was performed according to other guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances". Test chemical nominal conc. used for the study were 10 mg/l and 1 mg/l (w/v), respectively. Range finding study involve the TLm (48 hr) ≥ 4000 mg/l on Rice fish (Oryzias latipes).The bioconcentration factor (BCF value) of substance sodium 4 -aminonaphthalene-1 -sulfonate on Cyprinus carpio was determined to be < 0.6 L/Kg at a conc. of 10 mg/l and < 6 L/Kg at a conc. of 1 mg/l, respectively.
On the basis of above results for target chemicalsodium hydrogen 8-aminonaphthalene-1,6-disulfonate (fromCompTox Chemistry Dashboard, 2017) and for its read across substance (from authoritative database J-CHECK, 2017 and EnviChem, 2014), it can be concluded that the BCF value of test substance sodium hydrogen 8-aminonaphthalene-1,6-disulfonate was estimated to be 2.46 which does not exceed the bioconcentration threshold of 2000, indicating that the chemical sodium hydrogen 8-aminonaphthalene-1,6-disulfonate is not expected to bioaccumulate in the food chain.
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