1,2-dichloro-3-nitrobenzene

Solubility in organic solvents / fat solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Principles of method if other than guideline:

secondary peer reviewed source, valid collection of data

GLP compliance:

not specified

Very soluble in organic solvents; soluble in ethanol, ether, acetone, benzene, petroleum ether; slightly soluble in chlorform

Executive summary:

Very soluble in organic solvents; soluble in ethanol, ether, acetone, benzene, petroleum ether; slightly soluble in chlorform

Reference 2

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Remarks:

No reliability is given as this is a summary entry for the BUA-report.

Justification for type of information:

Due to insufficient reporting of the experimental details, this study was rated with a Klimisch score of 4 (‘not assignable’). As none of the available studies can serve as a key study with a sufficiently detailed reporting justifying a Klimisch score of 1 or 2 for the given endpoint, several independent sources were used in a weight of evidence approach. The combined data from handbooks or collection of data provide experimental values in a similar range, supporting the reliability of the result.

Principles of method if other than guideline:

BUA-report

GLP compliance:

not specified

Medium:

methanol

Solubility:

123 g/L

Temp.:

20 °C

Medium:

ethanol

Solubility:

115 g/L

Temp.:

20 °C

Medium:

diethyl ether

Solubility:

503 g/L

Temp.:

20 °C

Medium:

benzene

Solubility:

1 115 g/L

Temp.:

20 °C

Medium:

other: carbon disulphide

Solubility:

491 g/L

Temp.:

20 °C

Medium:

other: carbon tetrachloride

Solubility:

434 g/L

Temp.:

20 °C

Medium:

other: chloroform

Solubility:

1 240 g/L

Temp.:

20 °C

Medium:

other: dichloromethane

Solubility:

1 714 g/L

Temp.:

20 °C

Executive summary:

1,2-dichloro-3-nitrobenzene is very soluble in organic solvents (solubility at 20 °C):

in methanol: 123 g/L

in ethanol: 115 g/L

in diethyl ether: 503 g/L

in benzene: 1115 g/L

in carbon disulphide: 491 g/L

in carbon tetrachloride: 434 g/L

in chloroform: 1240 g/L

in dichloromethane: 1714 g/L

Description of key information

The individual study reports (data from handbooks or collection of data) show some deficiencies with respect to the comprehensiveness of the experimental details. Therefore, a reliability of 1 or 2 and thus adequacy as key study was not assignable for any of the individual studies. Consequently, the studies were assigned a Klimisch score of 4 (according to guidance document R.4, ‘not assignable: studies or data […] which are only listed in short abstracts or secondary literature (books, reviews, etc.)). As the individual studies report values in a similar range, collectively, these studies can be used to conclude on this endpoint.

1,2-dichloro-3-nitrobenzene is very soluble in organic solvents (solubility at 20 °C).

BUA-report, 1990

in methanol: 123 g/L

in ethanol: 115 g/L

in diethyl ether: 503 g/L

in benzene: 1115 g/L

in carbon disulphide: 491 g/L

in carbon tetrachloride: 434 g/L

in chloroform: 1240 g/L

in dichloromethane: 1714 g/L

HSDB, 2009

Very soluble in organic solvents; soluble in ethanol, ether, acetone, benzene, petroleum ether; slightly soluble in chlorform