Registration Dossier
Registration Dossier
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EC number: 206-076-3 | CAS number: 299-29-6
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- yes
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- other: ICP-OES and ICP-MS
- Key result
- Type:
- log Pow
- Partition coefficient:
- <= -2.6
- Temp.:
- 25 °C
- pH:
- ca. 4.33
- Conclusions:
- The log Pow of <-2.6 was obtained for the test item using a shake flask method.
Reference
Analytical results for partition coefficient
| Test 1A | Test 1B | Test 2A | Test 2B | Test 3A | Test 3B | |
| pH of water layer | 4.17 | 4.29 | 4.44 | 4.44 | 4.31 | 4.30 |
| logP | <-2.947 | <-2.959 | <-2.668 | <-2.664 | <-2.350 | <-2.337 |
| log mean P for determinations | <-2.59 | |||||
Stability:
The stability of stock solutions was checked alongside sample analysis.
The recovery values were approximately 10% lower than the theoretical value. This is consitent with the recoveries of the water layers from the test solutions and is deemed to show that there has been no significant degradation of the stock solutions in terms of concentration over the test period. Given the extremely high solubility in water observed during the studies, a 10% difference is not expected to significantly affect the determined results.
Description of key information
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
The log Pow of <-2.6 was obtained for the iron gluconate.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -2.6
- at the temperature of:
- 25 °C
Additional information
The mean logP value of <-2.6 at 25°C (Baldwin 2014, Partition Coefficient Data for REACH Substances) was determined for iron gluconate in a reliable study conducted according to an appropriate standard test method (OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)).
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