Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 289-339-5 | CAS number: 87741-01-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- other: EU Risk Assessment
- Adequacy of study:
- other information
- Reliability:
- other:
Data source
Reference
- Reference Type:
- other: EU Risk Assessment
- Title:
- European Union Risk Assessment Report 1,3-BUTADIENE, CAS No: 106-99-0, EINECS No:203-450-8
- Author:
- [ECB] European Chemicals Bureau
- Year:
- 2 002
Materials and methods
- Principles of method if other than guideline:
- EU Risk Assessment on the major component of C4 Hydrocarbons: 1,3-Butadiene
- GLP compliance:
- no
Test material
- Reference substance name:
- Buta-1,3-diene
- EC Number:
- 203-450-8
- EC Name:
- Buta-1,3-diene
- Cas Number:
- 106-99-0
- Molecular formula:
- C4H6
- IUPAC Name:
- buta-1,3-diene
- Details on test material:
- - Name of test material (as cited in study report): 1,3-butadiene
1,3-butadiene is the major and toxicologically most relevant component of C4-Hydrocarbons
(see attached document 'Read Across C4 Hydrocarbons' under chapter 13).
Constituent 1
Results and discussion
Any other information on results incl. tables
No skin irritation data are available for butadiene. The gaseous nature of butadiene precludes the conduct of conventional skin and eye irritation tests in animals.
However, as no skin irritation has been mentioned in any studies in humans following single exposure to high concentrations, this suggests that butadiene does not exhibit this property.
Applicant's summary and conclusion
- Executive summary:
No skin irritation in animals or humans were observed.
The gaseous nature of butadiene precludes the conduct of conventional skin and eye irritation tests in animals.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
