Registration Dossier
Registration Dossier
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EC number: 289-339-5 | CAS number: 87741-01-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: EU Risk Assessment
- Adequacy of study:
- other information
- Reliability:
- other:
Data source
Referenceopen allclose all
- Reference Type:
- other: EU Risk Assessment
- Title:
- European Union Risk Assessment Report 1,3-BUTADIENE, CAS No: 106-99-0, EINECS No:203-450-8
- Author:
- [ECB] European Chemicals Bureau
- Year:
- 2 002
- Reference Type:
- publication
- Title:
- Toxicohygienic characteristics of 1,3-butadiene
- Author:
- Ripp, G.K.
- Year:
- 1 969
- Bibliographic source:
- Tr Omsk Med Inst. 88; 10-18 (NTC translation 75-13092-06T)
Materials and methods
- Principles of method if other than guideline:
- EU Risk Assessment on the major component of C4 Hydrocarbons: 1,3-Butadiene
Test material
- Reference substance name:
- Buta-1,3-diene
- EC Number:
- 203-450-8
- EC Name:
- Buta-1,3-diene
- Cas Number:
- 106-99-0
- Molecular formula:
- C4H6
- IUPAC Name:
- buta-1,3-diene
- Details on test material:
- - Name of test material (as cited in study report): 1,3-butadiene
1,3-butadiene is the major and toxicologically most relevant component of C4-Hydrocarbons
(see attached document 'Read Across C4 Hydrocarbons' under chapter 13).
Constituent 1
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 5 480 mg/kg bw
- Remarks on result:
- other: rat
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 210 mg/kg bw
- Remarks on result:
- other: mouse
Any other information on results incl. tables
EU Risk Assessment on the major component of C4 Hydrocarbons: 1,3-Butadiene
Oral LD50 values of 5,480 mg/kg and 3,210 mg/kg have been reported for the rat and mouse respectively (Ripp, 1969).
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
The acute oral toxicity is judged to be low (LD50 > 2000 mg/kg)
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