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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Samarium chloride at all concentrations up to 1% used in the diet produced no histopathological changes in any of the organs studied.

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Link to relevant study records
Reference
Endpoint:
sub-chronic toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method B.30 (Chronic Toxicity Studies)
GLP compliance:
not specified
Species:
rat
Strain:
not specified
Sex:
male/female
Route of administration:
oral: feed
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
The chronic toxicity of samarium chlorides was determined by including 0.01, 0.l and 1% of the compound in the diet and feeding it over a period of 12 weeks to 3 groups of rats.
Remarks:
Doses / Concentrations:
0.01 %
Basis:
nominal in diet
Remarks:
Doses / Concentrations:
0.1 %
Basis:
nominal in diet
Remarks:
Doses / Concentrations:
1%
Basis:
nominal in diet
No. of animals per sex per dose:
6 per sex and dose
Control animals:
yes
Observations and examinations performed and frequency:
Observations were made of the following: total erythrocytes, total leucocytes, differential cell count, haemoglobin, haematocrit and body weight.
Sacrifice and pathology:
At the conclusion of the study the following tissues were examined histologically: heart, lung, liver, kidney, pancreas, spleen, adrenal and small intestine.
Histopathological findings: non-neoplastic:
no effects observed
Histopathological findings: neoplastic:
no effects observed
Details on results:
Samarium chloride at all concentrations up to 1% used in the diet produced no histopathological changes in any of the organs studied.
Dose descriptor:
NOAEL
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: 1% in feed over a period of 12 weeks
Remarks on result:
not determinable
Remarks:
no NOAEL identified
Critical effects observed:
not specified
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Study duration:
chronic
Species:
rat

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: inhalation - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint:
Test material is same like Samarium chloride.

Justification for classification or non-classification

There is conclusive data available which is not sufficient for classification.