Samarium (III) oxide

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given (comparable to guidelines/standards)

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Guideline of the Department of Transportation (D.O.T), Code of Federal Regulations, Title 49, Part 173

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Lanthanum carbonate

IUPAC Name:

Lanthanum carbonate

Constituent 2

Reference substance name:

54451-24-0

EC Number:

611-146-5

Cas Number:

54451-24-0

IUPAC Name:

54451-24-0

Details on test material:

- Name of test material (as cited in study report): Rare Earth Carbonate #1451
- Molecular formula (if other than submission substance): La2(CO3)3*H2O
- Analytical purity: no data

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Taconic Farms Inc.
- Weight at study initiation: males: 113 g, females: 109 g
- Fasting period before study: overnight
- Housing: 5 per wire mesh suspended cage
- Diet: Purina laboratory Chow, freely available
- Water: freely available
- Acclimation period: 7 days

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 50%

MAXIMUM DOSE VOLUME APPLIED: 6.0 -7.5 mL

Doses:

Range finding: 3980, 6320 and 10000 mg/kg
Main study: 31600 mg/kg

No. of animals per sex per dose:

Range finding: 2 (no information about sex)
Main test: 5

Control animals:

no

Details on study design:

- Clinical signs were noted immediately after dosing and at 4, 24 and 48 hours
- Body weight were recorded at dosing and at 48 h
- Animals found dead or terminated after 48 h were subjected to a macroscopic examination of the viscera

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 30 404 mg/kg bw

Remarks on result:

other: recalculated value to Lanthanum carbonate

Effect levels 2

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 31 600 mg/kg bw

Based on:

test mat.

Remarks on result:

other: original value: Lanthanum carbonate monohydrate

Mortality:

Range finding: no mortality after 48 h
Main study: no mortality after 48 h

Clinical signs:

other: Animals appeared normal after dosing

Gross pathology:

Macroscopic changes were not observed in the viscera.