Registration Dossier
Registration Dossier
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EC number: 263-454-0 | CAS number: 62202-86-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
In vitro testing is waived as the substance is pyrophoric, corrosive and water reactive
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Conclusions:
- Corrosive. Flammable in air at room temperature. Thus, exposure of bacteria in an in vitro mutagenicity test to magnesium alkyls would not generate meaningful data, and no mutagenicity study is required for this substance.
- Executive summary:
Corrosive. Flammable in air at room temperature. Thus, exposure of bacteria in an in vitro mutagenicity test to magnesium alkyls would not generate meaningful data, and no mutagenicity study is required for this substance.
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Conclusions:
- Corrosive. Flammable in air at room temperature. Thus, exposure of bacteria in an in vitro mutagenicity test to magnesium alkyls would not generate meaningful data, and no mutagenicity study is required for this substance.
- Executive summary:
Corrosive. Flammable in air at room temperature. Thus, exposure of bacteria in an in vitro mutagenicity test to magnesium alkyls would not generate meaningful data, and no mutagenicity study is required for this substance.
- Endpoint:
- in vitro gene mutation study in mammalian cells
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
- Conclusions:
- Corrosive. Flammable in air at room temperature. Thus, exposure of bacteria in an in vitro mutagenicity test to magnesium alkyls would not generate meaningful data, and no mutagenicity study is required for this substance.
- Executive summary:
Corrosive. Flammable in air at room temperature. Thus, exposure of bacteria in an in vitro mutagenicity test to magnesium alkyls would not generate meaningful data, and no mutagenicity study is required for this substance.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no study available
Genetic toxicity in vivo
Description of key information
the substance is pyrophoric, corrosive and water reactive
Link to relevant study records
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Corrosive. Flammable in air at room temperature.
Magnesium alkyls are highly reactive both towards oxygen (air) and water as explained below. Almost all magnesium alkyls are infusible solids, however, because of difficulties in handling undiluted magnesium alkyl and the manufacturing processes used, they are exclusively marketed in liquid state (hydrocarbon solutions) and shipped under UN transport class 4.2 (substances liable to spontaneous combustion / pyrophoric liquids) or at least under class 4.3 (substances which in contact with water emit flammable gases). Thus, these in vitro tests are technically not feasible to conduct and are scientifically unjustified.
Magnesium alkyls in general are highly reactive towards oxidizing agents including molecular oxygen, thus reacting spontaneously in air. Neat magnesium alkyls also ignite spontaneously on contact to air and therefore are classified pyrophoric.
Reactions of magnesium alkyls with liquids are in some cases explosion like. Most prominent example is reaction with water, which liberates for short chain alkyls highly flammable gases within seconds (alkyl groups with five carbon atoms and less). But any substance bearing protic hydrogen react in similar fashion, like alcohols, acids (organic and inorganic), etc.
Short description of key information:
Corrosive. Flammable in air at room temperature. According to the Annex VII Standard Information Requirements for REACH, an in vitro gene mutation study in bacteria is required. A specific rule for adaptation for not conducting this test is not stated. However, there are mitigating circumstances as to why this test cannot be conducted.
Justification for classification or non-classification
Corrosive. Flammable in air at room temperature. According to the Annex VII Standard Information Requirements for REACH, an in vitro gene mutation study in bacteria is required. A specific rule for adaptation for not conducting this test is not stated. However, there are mitigating circumstances as to why this test cannot be conducted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
