Butylethylmagnesium

Endpoint summary

Description of key information

Corrosive. Reactions of magnesium alkyls with liquids are in some cases explosion like. Most prominent example is reaction with water, which liberates for short chain alkyls highly flammable gases within seconds (alkyl groups with five carbon atoms and less). But any substance bearing protic hydrogen react in similar fashion, like alcohols, acids (organic and inorganic), etc.

Thus, exposure of mammalian species to magnesium alkyls would not generate meaningful data, and no acute toxicity studies are required for this substance.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Data waiving:

study technically not feasible

Justification for data waiving:

other:

Conclusions:

Corrosive. Flammable in air at room temperature. Violent reaction with water. Exposure of mammalian species to magnesium alkyls would not generate meaningful data, and no acute oral toxicity studies are required for this substance.

Executive summary:

Corrosive. Flammable in air at room temperature.Violent reaction with water. Exposure of mammalian species to magnesium alkyls would not generate meaningful data, and no acute oral toxicity studies are required for this substance.

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via inhalation route

Link to relevant study records

Reference

Endpoint:

acute toxicity: inhalation

Data waiving:

study technically not feasible

Justification for data waiving:

other:

Conclusions:

Exposure of mammalian species to magnesium alkyls would not generate meaningful data, and no acute inhalation toxicity studies are required for this substance.

Executive summary:

Exposure of mammalian species to magnesium alkyls would not generate meaningful data, and no acute toxicity studies are required for this substance.

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Link to relevant study records

Reference

Endpoint:

acute toxicity: dermal

Data waiving:

study technically not feasible

Justification for data waiving:

other:

Conclusions:

Corrosive. Flammable in air at room temperature. Violent reaction with water. Exposure of mammalian species to magnesium alkyls would not generate meaningful data, and no acute dermal toxicity studies are required for this substance.

Executive summary:

Corrosive. Flammable in air at room temperature.Violent reaction with water. Corrosive. Exposure of mammalian species to magnesium alkyls would not generate meaningful data, and no acute dermal toxicity studies are required for this substance.

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

According to the Annex VII Standard Information Requirements for REACH, 8.5.1 of the assessment of the acute toxicity endpoint, an acute toxicity test by the oral route is required. A specific rule for adaptation for the acute toxicity study/ies states that the study(ies) do not need to be conducted if – the substance is classfied as corrosive to the skin.   

 

Magnesium alkyls are highly reactive both towards oxygen (air) and water as explained below. Almost all magnesium alkyls are infusible solids, however, because of difficulties in handling undiluted magnesium alkyl and the manufacturing processes used, they are exclusively marketed in liquid state (hydrocarbon solutions) and shipped under UN transport class 4.2 (substances liable to spontaneous combustion / pyrophoric liquids) or at least under class 4.3 (substances which in contact with water emit flammable gases). Thus, these in vitro tests are technically not feasible to conduct and are scientifically unjustified.

 

Magnesium alkyls in general are highly reactive towards oxidizing agents including molecular oxygen, thus reacting spontaneously in air. Neat magnesium alkyls also ignite spontaneously on contact to air and therefore are classified pyrophoric.

 

Reactions of magnesium alkyls with liquids are in some cases explosion like. Most prominent example is reaction with water, which liberates for short chain alkyls highly flammable gases within seconds (alkyl groups with five carbon atoms and less). But any substance bearing protic hydrogen react in similar fashion, like alcohols, acids (organic and inorganic), etc.

 

Thus, exposure of mammalian species to magnesium alkyls would not generate meaningful data, and no acute oral toxicity studies are required for this substance.

Justification for classification or non-classification

A specific rule for adaptation for the acute toxicity studies states that the studies do not need to be conducted if - the substance is classified as corrosive to the skin.