Registration Dossier
Registration Dossier
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EC number: 204-979-7 | CAS number: 130-17-6
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original Report not available.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Guideline:
- EPA OPPTS 870.5385 (In Vivo Mammalian Cytogenetics Tests: Bone Marrow Chromosomal Analysis)
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- 2-(4-aminophenyl)-6-methylbenzothiazole-7-sulphonic acid
- EC Number:
- 204-979-7
- EC Name:
- 2-(4-aminophenyl)-6-methylbenzothiazole-7-sulphonic acid
- Cas Number:
- 130-17-6
- Molecular formula:
- C14H12N2O3S2
- IUPAC Name:
- 2-(4-aminophenyl)-6-methyl-1,3-benzothiazole-7-sulfonic acid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- B6C3F1
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Duration of treatment / exposure:
- 90 d
- Frequency of treatment:
- FEED x 90, 90 Days
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0.3 mg/kg
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
0.5 mg/kg
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
1 mg/kg
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
2 mg/kg
Basis:
nominal in diet
- Remarks:
- Doses / Concentrations:
4 mg/kg
Basis:
nominal in diet
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
Examinations
- Tissues and cell types examined:
- NCE
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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