Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-293-5 | CAS number: 7486-38-6
Endpoint summary
Administrative data
Description of key information
Additional information
For disodium adipate, no data on toxicity towards aquatic organisms are
available,
and a read-across approach with adipic acid is applied. In aqueous
media, disodium adipate and adipic acid acid dissociate into the
corresponding anion (1,6-hexandioic acid ion) and the sodium ion and
hydrogen ion (proton), respectively. Fate, behavior and the
ecotoxicological properties of adipic acid and its disodium salt are
thought to be an effect of the di-carboxylate ion rather than of the
sodium ion or the hydrogen ion (proton), which are normal constituents
in environmental systems and have no relevant ecotoxic properties in low
concentrations.
Therefore a read-across between disodium adipate and adipic acid is
justified and the
IUCLID dataset and the present Environmental Hazard Assessment is based
on the recent OECD/ICCA evaluation of adipic acid.
Adipic acid is a weak to medium strong acid and partly dissociates in water causing a pH shift (pKa1: 4.34; pKa2: 5.44). The tolerance of water organisms towards pH is diverse. Recommended pH values for test species listed in OECD guidelines are between 6 and 9.
Acute toxicity of adipic acid to fish (Danio rerio) was assessed in a static bioassay according to a national standard method. After 96 hours of exposure, a LC0 of > 1000 mg/l was obtained.
Adipic acid was tested with respect to the acute toxicity towards invertebrates (Dapnia magna) in a static test yielding in an 48 h-EC50 of 46 mg/l.
Concerning the toxicity to algae, the fresh water alga Pseudokirchnerella subcapitata was exposed to adipic acid for 72 hours. The experiment was conducted according to OECD Guideline 201 (Alga, Growth Inhibition Test). The test determined a 72-h EC50 value for effects on growth rate of 59 mg/L and a 72 -h EC10 of 41 mg/L.
The long-term toxicity test of adipic acid towards aquatic invertebrates (Dapnia magna) was investigated in a reproduction test according OECD Guideline 211. After 21 days of exposure a NOEC-reproduction of 6.3 mg/l was determined.
Assessing the toxicity towards microorganisms, a growth inhibition test with Tetrahymena pyriformis was performed using adipic acid as test substance. An 40h-IC50 of 591 mg/L was observed. In an additional study with activated sludge an EC50 (3 hours) of 4747 mg/L was determined in a test according to the OECD 209 (respiration inhibition).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
