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EC number: 207-317-5 | CAS number: 461-82-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June to October 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Experimental procedures are only briefly described
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-(trifluoromethoxy)aniline
- EC Number:
- 207-317-5
- EC Name:
- 4-(trifluoromethoxy)aniline
- Cas Number:
- 461-82-5
- Molecular formula:
- C7H6F3NO
- IUPAC Name:
- 4-(trifluoromethoxy)aniline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann (Borchen), Germany
- Weight at study initiation: 160-220 g
- Fasting period before study: 16 hours
- Housing: Makrolon cages, type III
- Diet: Altromin-R-haltungsdiät
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 6 x 8 cm, based on the method of Noakes and Sanderson (Brit. J. Ind. Med. 26, 59, 1969)
- % coverage: not reported
- Type of wrap if used: occlusive
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Treated skin was cleaned with soap and water
- Time after start of exposure: Skin was cleaned 24 hours after exposure
TEST MATERIAL
- Amount(s) applied: not specified - Duration of exposure:
- 24 hours
- Doses:
- Males:
- 33 mg/kg bw
- 66 mg/kg bw
- 99 mg/kg bw
- 132 mg/kg bw
- 330 mg/kg bw
Females
- 3 mg/kg bw
- 66 mg/kg bw
- 99 mg/kg bw
- 132 mg/kg bw - No. of animals per sex per dose:
- 10 animals/sex/dose except for females in the 132 mg/kg bw dose group, which had 5 animals
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not specified
- Necropsy of survivors performed: yes
- Clinical signs of toxicity were observed and reported. - Statistics:
- Calculation of the median lethal dose (LD50) was done according to Litchfield and Wilcoxon (J. Pharmac. Exper. Therap. 96, 99, 1949).
Results and discussion
- Preliminary study:
- Preliminary study not conducted
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 33 - <= 66 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 84.5 mg/kg bw
- Based on:
- test mat.
- Mortality:
- For males, mortality occurred at doses of greater than or equal to 66 mg/kg bw. At these dose levels, 2, 7, 9, and 10 animals died at 66, 99, 132, and 330 mg/kg bw, respectively. For females, mortality occurred at doses of greater than or equal to 66 mg/kg bw. At these dose levels, 8, 10, 5 females died at 66, 99, and 132 mg/kg bw, respectively.
- Clinical signs:
- other: The clinical signs of toxicity included apathy, shallow and faster breathing, cyanosis, lying on side/prostration.
- Gross pathology:
- Necropsy of the animals that died prior to sacrifice revealed a clay to rusty-brown coloring of the lungs. There were isolated cases of emphysema of the lung and slightly enlarged thymus glands. For those animals that survived until scheduled necropsy, there were no gross findings.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 based on GHS criteria
- Conclusions:
- In a study conducted in a similar method to OECD 402, the LD50 for male rats was 84.5 mg/kg bw and the LD50 for female rats was within the range of 33 - 66 mg/kg bw. Based on the most sensitive gender, classification as Cat 1 in warranted with respect to acute dermal toxicity.
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