Monopentaerythritol tetraesters and dipentaerythritol hexaesters of 2-ethylhexanoic and n-valeric acids

Toxicity to soil macroorganisms except arthropods

Link to relevant study record(s)

Reference

Endpoint:

toxicity to soil macroorganisms except arthropods: long-term

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Remarks:

Summary of available data used for the endpoint assessment of the target substance

Adequacy of study:

key study

Justification for type of information:

Please refer to the Analogue Justification provided in IUCLID Section 13.

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

other:

Duration:

28 d

Dose descriptor:

NOEC

Effect conc.:

>= 1 000 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Remarks on result:

other: source, CAS 68443-84-5, Nyco, 2013, Eisenia fetida, RL1

Duration:

28 d

Dose descriptor:

NOEC

Effect conc.:

>= 1 000 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth

Remarks on result:

other: source, CAS 68443-84-5, Nyco, 2013, Eisenia fetida, RL1

Duration:

56 d

Dose descriptor:

NOEC

Effect conc.:

>= 1 000 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

reproduction

Remarks on result:

other: source, CAS 68443-84-5, Nyco, 2013, Eisenia fetida, RL1

Duration:

28 d

Dose descriptor:

LOEC

Effect conc.:

> 1 000 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Remarks on result:

other: source, CAS 68443-84-5, Nyco, 2013, Eisenia fetida, RL1

Duration:

28 d

Dose descriptor:

LOEC

Effect conc.:

> 1 000 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth

Remarks on result:

other: source, CAS 68443-84-5, Nyco, 2013, Eisenia fetida, RL1

Duration:

56 d

Dose descriptor:

LOEC

Effect conc.:

> 1 000 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

reproduction

Remarks on result:

other: source, CAS 68443-84-5, Nyco, 2013, Eisenia fetida, RL1

Duration:

14 d

Dose descriptor:

NOEC

Effect conc.:

>= 1 000 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Remarks on result:

other: source, CAS 71010-76-9, Exxon, 2013, Eisenia fetida, RL2

Description of key information

NOEC (56 d) ≥ 1000 mg/kg dw, read-across.

Key value for chemical safety assessment

Long-term EC10, LC10 or NOEC for soil macroorganisms:

1 000 mg/kg soil dw

Additional information

No study investigating the toxicity of Monopentaerythritol tetraesters and dipentaerythritol hexaesters of 2-ethylhexanoic and n-valeric acids to soil macroorganisms is available. Therefore, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substances Triisononanoic acid, triester with 2,2’-[oxybis(methylene)]bis[2-(hydroxymethyl)propane-1,3-diol] tris(2-ethylhexanoate) (CAS 68443-84-5) and Decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9) is applied.

Based on the high degree of similarity between the structural and physico-chemical properties of the target and source substance, the source substance is considered suitable representative for the evaluation of the toxicity of the target substance to soil macroorganisms. The read-across approach is justified in detail within the analogue justification in IUCLID section 13.

The study with the source substance Triisononanoic acid, triester with 2,2’-[oxybis(methylene)]bis[2-(hydroxymethyl)propane-1,3-diol] tris(2-ethylhexanoate) (CAS 68443-84-5) was performed according to OECD 222. The effect of the test substance on earthworm survival, growth and reproduction was investigated. The test was conducted with artificial soil that was mixed with the test substance. Eisenia fetida was exposed to the test substance for 28 days and then removed from the test substrate. The survival rate and growth (body weight) of the specimen were determined. After another 28 days the hatched juveniles were collected from the test substrate and the reproduction rate was recorded. Mortality, a decrease in body weight of the adult earthworms or inhibition of reproduction was not observed. Thus a NOEC (56 d) ≥ 1000 mg/kg soil based on the reproduction rate was determined.

An acute test with source substance Decanoic acid, mixed esters with heptanoic acid, octanoic acid, pentaerythritol and valeric acid (CAS 71010-76-9) was conducted according to OECD 207.Eisenia fetidawas exposed to a test concentration of 1000 mg/kg dw in artificial soil for 14 days. Mortality was recorded at the end of the study. 100% survival was observed in both the control group and treatment group resulting in a NOEC (14 d) for mortality of ≥ 1000 mg/kg dw.

Based on the available results from structurally related source substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that Monopentaerythritol tetraesters and dipentaerythritol hexaesters of 2-ethylhexanoic and n-valeric acids will not exhibit effects to soil macroorganisms.